1-Tert-butyl 3-Methyl 5,5-difluoropiperidine-1,3-dicarboxylate

Base Information

• Chemical Name: 1-Tert-butyl 3-Methyl 5,5-difluoropiperidine-1,3-dicarboxylate
• CAS No.: 1255667-06-1
• Molecular Formula: C₁₂H₁₉F₂NO₄
• Molecular Weight: 279.284
• Hs Code.: 2933399990
• Mol file: 1255667-06-1.mol

Synonyms:

Chemical Property of 1-Tert-butyl 3-Methyl 5,5-difluoropiperidine-1,3-dicarboxylate

Chemical Property:

• Boiling Point: 311.4±42.0 °C(Predicted)
• PKA: -6.54±0.60(Predicted)
• Density: 1.19±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-tert-butyl3-methyl5,5-difluoropiperidine-1,3-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Tert-butyl 3-Methyl 5,5-difluoropiperidine-1,3-dicarboxylate

There total 10 articles about 1-Tert-butyl 3-Methyl 5,5-difluoropiperidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(tert-butyl) 3-methyl 5-oxopiperidine-1,3-dicarboxylate (1303974-96-0) → 1-(tert-butyl) 3-methyl 5,5-difluoropiperidine-1,3-dicarboxylate (1255667-06-1)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; under 760.051 Torr; Inert atmosphere;

Reference yield:

1-(1,1-dimethylethyl) 3-methyl 5-hydroxy-1,3-piperidinedicarboxylate (1095010-47-1,1246442-45-4) → 1-(tert-butyl) 3-methyl 5,5-difluoropiperidine-1,3-dicarboxylate (1255667-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / 760.05 Torr / Inert atmosphere

With diethylamino-sulfur trifluoride; Dess-Martin periodane; In dichloromethane;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 5,5-difluoro-piperidine-3-carboxylic acid methyl ester → 1-(tert-butyl) 3-methyl 5,5-difluoropiperidine-1,3-dicarboxylate (1255667-06-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

1-(1,1-dimethylethyl) 3-methyl 5-hydroxy-1,3-piperidinedicarboxylate

1-(tert-butyl) 3-methyl 5-oxopiperidine-1,3-dicarboxylate

methyl 5-hydroxy-3-pyridinecarboxylate

5-hydroxynicotinic acid

Downstream raw materials:

tert-butyl 3,3-difluoro-5-(hydroxymethyl)piperidine-1-carboxylate

1-(tert-butoxycarbonyl)-5,5-difluoropiperidine-3-carboxylic acid