1303974-96-0

Basic information

• Product Name: Methyl 1-Boc-5-oxo-piperidine-3-carboxylate
• Synonyms: Methyl 1-Boc-5-oxo-piperidine-3-carboxylate;1-(tert-butoxycarbonyl)-3-methyl-5-oxopiperidine-3-carboxylic acid
• CAS NO: 1303974-96-0
• Molecular Formula: C12H19NO5
• Molecular Weight: 257.28296
• Mol File: 1303974-96-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 1-Boc-5-oxo-piperidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-Boc-5-oxo-piperidine-3-carboxylate(1303974-96-0)
• EPA Substance Registry System: Methyl 1-Boc-5-oxo-piperidine-3-carboxylate(1303974-96-0)

Safety Data

• Hazardous Substances Data: 1303974-96-0(Hazardous Substances Data)

Usage

Description

Methyl 1-Boc-5-oxo-piperidine-3-carboxylate is a chemical compound with the molecular formula C12H19NO5, derived from piperidine, a cyclic amine. It features a tert-butyloxycarbonyl (1-Boc) protecting group and an oxo group, indicating the presence of a carbonyl group. Methyl 1-Boc-5-oxo-piperidine-3-carboxylate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and is typically handled under strict laboratory conditions due to its potential reactivity and toxicity.

Uses

Used in Pharmaceutical Industry:
Methyl 1-Boc-5-oxo-piperidine-3-carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals. Its 1-Boc protecting group allows for selective reactions to occur at other sites on the molecule, facilitating the production of complex drug molecules.
Used in Agrochemical Industry:
In the agrochemical industry, Methyl 1-Boc-5-oxo-piperidine-3-carboxylate serves as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Organic Synthesis:
Methyl 1-Boc-5-oxo-piperidine-3-carboxylate is utilized in organic synthesis for the preparation of various organic compounds. Its functional groups, including the carbonyl and the Boc protecting group, enable a range of reactions that can be employed to construct diverse organic molecules.

Upstream product

• 1246442-45-4 rac-(3R,5S)-[1-(tert-butyl) 3-methyl 5-hydroxypiperidine-1,3-dicarboxylate] 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1095010-48-2 1-(tert-butoxycarbonyl)-5-hydroxypiperidine-3-carboxylic acid 
• 1095010-44-8 methyl 5-hydroxypiperidine-3-carboxylate 
• 27828-71-3 5-hydroxynicotinic acid 
• 30766-22-4 methyl 5-hydroxy-3-pyridinecarboxylate 
• 1095010-47-1 1-(1,1-dimethylethyl) 3-methyl 5-hydroxy-1,3-piperidinedicarboxylate 

Downstream Products

• 1255666-86-4 1-(tert-butoxycarbonyl)-5,5-difluoropiperidine-3-carboxylic acid 
• 1262412-64-5 tert-butyl 3,3-difluoro-5-(hydroxymethyl)piperidine-1-carboxylate 
• 1255667-06-1 1-(tert-butyl) 3-methyl 5,5-difluoropiperidine-1,3-dicarboxylate 

Relevant articles and documents

PHENOXY-PYRIDYL-PYRIMIDINE COMPOUNDS AND METHODS OF USE

Described herein are phenoxy-pyridyl -pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Novel Allosteric Ligands of γ-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries

This study describes the screening of dynamic combinatorial libraries based on nipecotic acid as core structure with substituents attached to the 5- instead of the common 1-position for the search of novel inhibitors of the GABA transporter GAT1. The generated pseudostatic hydrazone libraries included a total of nearly 900 compounds and were screened for their binding affinities toward GAT1 in competitive mass spectrometry (MS) based Binding Assays. Characterization of the hydrazones with the highest affinities (with cis-configured rac-16gf bearing a 5-(1-naphthyl)furan-2-yl residue and a four atom spacer being the most potent) in binding and uptake experiments revealed an allosteric interaction at GAT1, which was not reported for any other nipecotic acid derivative up to now. Therefore, the herein introduced 5-substituted nipecotic acid derivatives could serve as valuable tools for investigations of allosterically modulated GABA transport mediated by GAT1 and furthermore as starting point for a new class of GAT1 inhibitors.

NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND

The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].