Chemical Property of PI-103
Chemical Property:
- Boiling Point:520.25 °C at 760 mmHg
- PKA:9.06±0.10(Predicted)
- Flash Point:268.438 °C
- PSA：84.51000
- Density:1.409 g/cm3
- LogP:3.84720
- Storage Temp.:Desiccate at +4°C
- Solubility.:Soluble in DMSO (up to 40 mg/ml)
- XLogP3:2.7
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:2
- Exact Mass:348.12224039
- Heavy Atom Count:26
- Complexity:489
- Purity/Quality:
-
99%, *data from raw suppliers
PI 103 hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O
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Description
PI-103 (371935-74-9) is a potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48,? 20, 83 and 2 nM for p110α, p110?, p110γ, p110δ, mTORC1, mTORC2 and DNA-PK respectively.1,2 Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation.3 Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines.4 Induces autophagy in drug-resistant glioma.5 Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.6
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Uses
PI 103 is a dual inhbitor of Class IA phosphatidylinositol 3-kinase and mammalian target of rapaymycin complex 1 (mTORC1), both of which are involved in pathways often activated in myelogenous leukemia. PI 103 also functions to enhance tumour radiosensitivity.
