Technology Process of (S)-9-(4-iodobenzyl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine
There total 5 articles about (S)-9-(4-iodobenzyl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
dichloromethane; isopropyl alcohol;
at 40 ℃;
for 48h;
Inert atmosphere;
DOI:10.1021/ja2092163
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / water / 0.5 h / 20 °C
2: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve
3: acetic acid / ethanol / 3 h / 60 °C
4: 6,6'-bis(9-anthracenyl)-1,1'-spirobiindane-7,7'-diyl-hydrogenphosphate / benzene / 30 °C / Inert atmosphere; Molecular sieve
5: hydrazine hydrate / dichloromethane; isopropyl alcohol / 48 h / 40 °C / Inert atmosphere
With
hydrazine hydrate; 6,6'-bis(9-anthracenyl)-1,1'-spirobiindane-7,7'-diyl-hydrogenphosphate; potassium carbonate; acetic acid; pyridinium chlorochromate;
In
ethanol; dichloromethane; water; isopropyl alcohol; benzene;
4: Fischer indolization;
DOI:10.1021/ja2092163
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 6,6'-bis(9-anthracenyl)-1,1'-spirobiindane-7,7'-diyl-hydrogenphosphate / benzene / 30 °C / Inert atmosphere; Molecular sieve
2: hydrazine hydrate / dichloromethane; isopropyl alcohol / 48 h / 40 °C / Inert atmosphere
With
hydrazine hydrate; 6,6'-bis(9-anthracenyl)-1,1'-spirobiindane-7,7'-diyl-hydrogenphosphate;
In
dichloromethane; isopropyl alcohol; benzene;
1: Fischer indolization;
DOI:10.1021/ja2092163
