Technology Process of (S)-4-fluoro-N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide
There total 19 articles about (S)-4-fluoro-N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2.) tetrabutylammonium borohydride, 3.) 2N sulfuric acid / 1.) benzene, reflux, 1 h, 2.) CH2Cl2, -50 deg C to room temperature, 3.) methanol, room temperature, 1 h
2: 1.) 2N NaOH, conc. HCl, 2.) ammonium formiate / 2.) 10percent Pd/C / 1.) methanol, ethyl acetate, 2.) dimethylformamide, reflux, 20 min
3: triethylamine / CH2Cl2 / 1 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; sulfuric acid; ammonium formate; tetrabutylammonium borohydride; triethylamine;
palladium on activated charcoal;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) 2N NaOH, conc. HCl, 2.) ammonium formiate / 2.) 10percent Pd/C / 1.) methanol, ethyl acetate, 2.) dimethylformamide, reflux, 20 min
2: triethylamine / CH2Cl2 / 1 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; ammonium formate; triethylamine;
palladium on activated charcoal;
In
dichloromethane;
- Guidance literature:
-
With
chiralpak IC;
In
hexane; isopropyl alcohol;
at 30 ℃;
Resolution of racemate;
DOI:10.1021/jo300552v