2-methylthieno[3,2-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 2-methylthieno[3,2-d]pyrimidin-4(3H)-one
• CAS No.: 18678-13-2
• Molecular Formula: C7H6N2OS
• Molecular Weight: 166.20
• Hs Code.: 2934999090
• Mol file: 18678-13-2.mol

Synonyms:Thieno[3,2-d]pyrimidin-4(1H)-one,2-methyl- (9CI);Thieno[3,2-d]pyrimidin-4-ol, 2-methyl- (8CI);2-Methylthieno[3,2-d]pyrimidin-4-ol;

Chemical Property of 2-methylthieno[3,2-d]pyrimidin-4(3H)-one

Chemical Property:

• Refractive Index: 1.726
• PSA: 73.99000
• Density: 1.456 g/cm³
• LogP: 1.29300
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Methylthieno[3,2-d]pyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methylthieno[3,2-d]pyrimidin-4(3H)-one

There total 10 articles about 2-methylthieno[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-acetamidothiophene-2-carboxamide (1037297-94-1) → 2-methylthieno[3,2-d]pyrimidin-4-ol (18678-13-2)

Guidance literature:

With sodium hydroxide; for 4h; Heating;

DOI:10.1016/j.bmcl.2008.03.075

Reference yield: 97.0%

ethyl 3-amino-2-thiophene-2-carboxylate hydrochloride (1611471-26-1) + thioacetamide (62-55-5) → 2-methyl-3H-thieno[3,2-d]pyrimidin-4-one (18678-13-2)

Guidance literature:

In neat (no solvent); Microwave irradiation;

DOI:10.1039/c4ob00175c

Reference yield: 73.0%

3-acetylamine-2-thiophenecarboxylic acid methyl ester (22288-79-5) → 2-methyl-3H-thieno[3,2-d]pyrimidin-4-one (18678-13-2)

Guidance literature:

With ammonium hydroxide; at 120 ℃; for 8h;

upstream raw materials:

Methyl 3-aminothiophene-2-carboxylate

O-ethyl acetimidate

acetonitrile

3-acetamidothiophene-2-carboxamide

Downstream raw materials:

4-chloro-2-methylthieno[3,2-d]pyrimidine

4-chloro-7-methylthieno[3,2-d]pyrimidine