2-Chloroimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-Chloroimidazo[1,2-a]pyridine
• CAS No.: 3999-05-1
• Molecular Formula: C7H5 Cl N2
• Molecular Weight: 152.583
• Hs Code.: 2933990090
• European Community (EC) Number: 838-600-7
• DSSTox Substance ID: DTXSID00366597
• Nikkaji Number: J1.628.248K
• Wikidata: Q72452070
• Mol file: 3999-05-1.mol

Synonyms:2-chloroimidazo[1,2-a]pyridine;3999-05-1;Imidazo[1,2-a]pyridine,2-chloro-;Imidazo[1,2-a]pyridine, 2-chloro-;2-Chloro-imidazo[1,2-a]pyridine;874373-51-0;SCHEMBL755953;DTXSID00366597;XDYIGMLMAVDTCE-UHFFFAOYSA-N;BCP26552;MFCD06335049;AKOS004121482;PB42746;AS-35688;CS-0077571;FT-0711552;EN300-16472;Z55928902

Chemical Property of 2-Chloroimidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 74.5-75.5℃
• PKA: 3.97±0.50(Predicted)
• PSA: 17.30000
• Density: 1.35±0.1 g/cm3 (20 oC 760 Torr)
• LogP: 1.98770
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 152.0141259
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

97% ^*data from raw suppliers

2-Chloroimidazo[1,2-a]pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC(=CN2C=C1)Cl

Technology Process of 2-Chloroimidazo[1,2-a]pyridine

There total 5 articles about 2-Chloroimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid (126202-06-0,479348-68-0) → 2-chloroimidazo[1,2-a]pyridine (3999-05-1)

Guidance literature:

With trichlorophosphate; In toluene; at 100 ℃; for 16h;

Reference yield: 76.0%

2-aminopyridine (504-29-0) + chloroacetic acid (79-11-8) → 2-chloroimidazo[1,2-a]pyridine (3999-05-1)

Guidance literature:

2-aminopyridine; chloroacetic acid; With triethylamine; In water; at 90 ℃; for 5h;

In ethanol; at 5 ℃; for 2h;

With trichlorophosphate; In toluene; Reflux;

DOI:10.1039/c7ob00624a

Reference yield:

ethyl 2-(2-iminopyridin-1(2H)-yl)acetate (785005-54-1) → 2-chloroimidazo[1,2-a]pyridine (3999-05-1)

Guidance literature:

With trichlorophosphate; at 105 ℃; for 3h;

upstream raw materials:

2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid

2-aminopyridine

chloroacetic acid

ethyl 2-(2-iminopyridin-1(2H)-yl)acetate

Downstream raw materials:

ethyl 2-chloroimidazo[1,2-a]pyridine-3-carboxylate

2-(4-fluorophenyl)-3-nitroimidazo[1,2-a]pyridine

3-nitro-2-(4'-nitrophenyl)imidazo[1,2-a]pyridine

2-phenylimidazo[1,2-a]pyridin-3-amine