EANBP-GABA-MBA

Base Information

• Chemical Name: EANBP-GABA-MBA
• CAS No.: 1374399-70-8
• Molecular Formula: C₃₇H₄₉N₃O₁₀
• Molecular Weight: 695.81
• Mol file: 1374399-70-8.mol

Synonyms:

Chemical Property of EANBP-GABA-MBA

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of EANBP-GABA-MBA

There total 7 articles about EANBP-GABA-MBA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxybenzoic acid (100-09-4) → EANBP-GABA-MBA (1374399-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 20 °C

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1002/anie.201106559

Reference yield:

N,N-Bis(2-(2-methoxyethoxy)ethyl)benzene amine (484679-02-9) → EANBP-GABA-MBA (1374399-70-8)

Guidance literature:

Multi-step reaction with 5 steps

1: iodine / 1,4-dioxane; pyridine / 2 h / 0 - 20 °C

2: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / ethanol; water / 0.17 h / 150 °C / Microwave irradiation

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 19 h / 0 - 20 °C

4: dichloromethane / 0.02 h / 20 °C / Inert atmosphere

5: N,N-dimethyl-formamide / 20 °C

With dmap; tetrabutylammomium bromide; iodine; palladium diacetate; potassium carbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;

DOI:10.1002/anie.201106559

Reference yield:

para-nitrophenyl bromide (586-78-7) → EANBP-GABA-MBA (1374399-70-8)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

3: diisobutylaluminium hydride / tetrahydrofuran / 3 h / 0 - 20 °C

4: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / ethanol; water / 0.17 h / 150 °C / Microwave irradiation

5: dmap; dicyclohexyl-carbodiimide / dichloromethane / 19 h / 0 - 20 °C

6: dichloromethane / 0.02 h / 20 °C / Inert atmosphere

7: N,N-dimethyl-formamide / 20 °C

With dmap; potassium tert-butylate; tetrabutylammomium bromide; palladium diacetate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 4: Suzuki coupling;

DOI:10.1002/anie.201106559

upstream raw materials:

tert-butyl 2-(5-bromo-2-nitrophenyl)ethanoate

1H-benzo[d][1,2,3]triazol-1-yl 4-methoxybenzoate

4-methoxybenzoic acid

para-nitrophenyl bromide