Technology Process of N-Benzoyl-N'-[3-(3,4-difluoro-phenyl)-3-phenyl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine
There total 8 articles about N-Benzoyl-N'-[3-(3,4-difluoro-phenyl)-3-phenyl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: β-alanine, acetic acid / toluene / Heating
2: benzene / 1 h / Heating
3: 5percent aq. NaOH / methanol / 0.25 h / Heating
4: 2.) LiAlH4 / 1.) tetraline, 160-165 deg C, 15 min, 2.) Et2O, reflux, 60 min
5: CH2Cl2 / 0.25 h / Ambient temperature
6: pyridine / 2 h / Heating
With
pyridine; sodium hydroxide; lithium aluminium tetrahydride; acetic acid; 3-amino propanoic acid;
In
methanol; dichloromethane; toluene; benzene;
DOI:10.1016/0223-5234(92)90145-Q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: CH2Cl2 / 0.25 h / Ambient temperature
2: pyridine / 2 h / Heating
With
pyridine;
In
dichloromethane;
DOI:10.1016/0223-5234(92)90145-Q
- Guidance literature:
-
Multi-step reaction with 5 steps
1: benzene / 1 h / Heating
2: 5percent aq. NaOH / methanol / 0.25 h / Heating
3: 2.) LiAlH4 / 1.) tetraline, 160-165 deg C, 15 min, 2.) Et2O, reflux, 60 min
4: CH2Cl2 / 0.25 h / Ambient temperature
5: pyridine / 2 h / Heating
With
pyridine; sodium hydroxide; lithium aluminium tetrahydride;
In
methanol; dichloromethane; benzene;
DOI:10.1016/0223-5234(92)90145-Q
