4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE
• CAS No.: 898044-50-3
• Molecular Formula: C5H4ClFN2
• Molecular Weight: 146.552
• Hs Code.: 2933599090
• Mol file: 898044-50-3.mol

Synonyms:4-Chloro-5-fluoro-2-methylpyrimidine;5-Fluoro-4-chloro-2-methylpyrimidine;

Chemical Property of 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE

Chemical Property:

• Vapor Pressure: 1.44mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 176.9 °C at 760 mmHg
• PKA: -0.65±0.29(Predicted)
• Flash Point: 60.8 °C
• PSA: 25.78000
• Density: 1.352 g/cm³
• LogP: 1.57750
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-5-fluoro-2-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-5-fluoro-2-methylpyrimidine

Technology Process of 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE

There total 2 articles about 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

5-fluoro-2-methylpyrimidin-4(3H)-one (1480-91-7) → 4-chloro-5-fluoro-2-methylpyrimidine (898044-50-3)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; at 110 ℃; for 1.5h;

Reference yield: 10.0%

→ 4-chloro-5-fluoro-2-methylpyrimidine (898044-50-3)

Guidance literature:

Reference yield: 25.0%

3-amino-6,6-dimethyl-N-((1R,2S)-2-phenylcyclopropyl)pyrrolo[3,4-c]pyrazole-5(1H,4,6H)-carboxamide + 4-chloro-5-fluoro-2-methylpyrimidine (898044-50-3) → C22H24FN7O

Guidance literature:

With acetic acid; In water; at 100 ℃; for 1h;

DOI:10.1016/j.tetlet.2011.01.148

upstream raw materials:

5-fluoro-2-methylpyrimidin-4(3H)-one

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