tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate

Base Information

• Chemical Name: tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate
• CAS No.: 1402164-73-1
• Molecular Formula: C₂₆H₃₀ClN₅O₄S
• Molecular Weight: 544.074
• Mol file: 1402164-73-1.mol

Synonyms:

Chemical Property of tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate

There total 4 articles about tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-3-chloro-5-methylbenzonitrile (158296-69-6) → tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate (1402164-73-1,917475-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / -20 - 65 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm300931y

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate (1402164-73-1,917475-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / dichloromethane; water / 6 h / 0 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water;

DOI:10.1021/jm300931y

Reference yield:

N-(tert-butyloxycarbonyl)-S-methylisothiourea (173998-77-1) → tert-butyl N-(4-amino-3-chloro-5-methylbenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisothiazole-4-carbonyl)carbamimidoylcarbamate (1402164-73-1,917475-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jm300931y

upstream raw materials:

di-tert-butyl dicarbonate

N-(tert-butyloxycarbonyl)-S-methylisothiourea

4-amino-3-chloro-5-methylbenzonitrile

N-(2-chloro-4-cyano-6-methylphenyl)acetamide

Downstream raw materials:

N-(amino(3-chloro-4-(2-(dimethylamino)acetamido)-5-methylbenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

N-(amino(4-(2-(benzylamino)acetamido)-3,5-dichlorobenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

N-(amino(3-chloro-4-(2-(ethylamino)acetamido)-5-methylbenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide

N-(amino(4-(2-(azetidin-1-yl)acetamido)-3-chloro-5-methylbenzylamino)methylene)-3-(4-methoxyphenyl)-5-methylisothiazole-4-carboxamide