Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester
CAS No.:1054645-97-4
Molecular Formula:C₄₈H₅₁N₆O₁₅P
Molecular Weight:982.938
Hs Code.:

Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

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Chemical Property of Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

Chemical Property:

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Technology Process of Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

There total 7 articles about Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57018-82-3,81352-25-2
5'-O-dimethoxytrityladenosine

: 1054645-97-4
Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 4.5 h / 0 °C

2: 48 percent / benzenesulphonic acid / CH₂Cl₂; methanol / 0.33 h

3: 0.17 h / Ambient temperature

4: 2.) H₂O / 1.) dioxane, 90 min, rt, 2.) 12 h, rt

With water; benzenesulfonic acid; In pyridine; methanol; dichloromethane;
DOI:10.1080/07328319808004322

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1054645-97-4
Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 1 h / Ambient temperature

2: 82 percent / H₂O / 2 h

3: 2.) H₂O / 1.) dioxane, 90 min, rt, 2.) 12 h, rt

With water; In diethyl ether; water;
DOI:10.1080/07328319808004322

Reference yield:

: 24123-12-4
1-(benzyloxycarbonyl)-3-methylimidazolium chloride

: 1054645-97-4
Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / H₂O / 2 h

2: 2.) H₂O / 1.) dioxane, 90 min, rt, 2.) 12 h, rt

With water; In water;
DOI:10.1080/07328319808004322