Tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
CAS No.:577691-56-6
Molecular Formula:C₁₀H₁₉FN₂O₂
Molecular Weight:218.271
Hs Code.:2933399990
European Community (EC) Number:824-643-9
DSSTox Substance ID:DTXSID401164106
Wikidata:Q76416886
Mol file:577691-56-6.mol

Synonyms:907544-17-6;TERT-BUTYL (3R,4S)-4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE;577691-56-6;CIS-4-AMINO-1-BOC-3-FLUOROPIPERIDINE;(3R,4S)-4-Amino-3-fluoropiperidine-1-carboxylic Acid tert-Butyl Ester;(3R,4S)-4-Amino-1-Boc-3-fluoropiperidine;(3R,4S)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate;tert-butyl (3R,4S)-4-amino-3-fluoro-piperidine-1-carboxylate;cis-1,1-dimethylethyl 4-amino-3-fluoro-1-piperidinecarboxylate;cis-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate;1-Boc-(3R,4S)-4-amino-3-fluoropiperidine;MFCD12912368;MFCD12912699;(3R,4S)-tert-butyl4-amino-3-fluoropiperidine-1-carboxylate;SCHEMBL1356253;ZQRYPCAUVKVMLZ-SFYZADRCSA-N;DTXSID401164106;AMY35459;AKOS022184816;AS-33785;A8225;CS-0048557;(3R,4S)-1-Boc-4-Amino-3-Fluoropiperidine;P16310;cis-(3R,4S)-1-Boc-4-amino-3-fluoropiperidine;cis-4-amino-1-tert-butoxycarbonyl-3-fluoropiperidine;(cis)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate;(cis)-tert-butyl-4-amino-3-fluoropiperidine-1-carboxylate;t-Butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate;cis(+/-)tert-butyl-4-amino-3-fluoropiperidine-1-carboxylate;tert-butyl cis(+/-)-4-amino-3-fluoropiperidine-1-carboxylate;tert-butyl(3R,4S)-4-amino-3-fluoro-piperidine-1-carboxylate;(+/-)-(cis)-tert-butyl-4-amino-3-fluoropiperidine-1-carboxylate;1,1-Dimethylethyl (3R,4S)-4-amino-3-fluoro-1-piperidinecarboxylate

Suppliers and Price of Tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
rel-tert-Butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate
1 g
$ 375.00

Matrix Scientific
(3S,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate 95+%
1g
$ 1647.00

Matrix Scientific
(3S,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate 95+%
250mg
$ 742.00

Crysdot
cis-tert-Butyl4-amino-3-fluoropiperidine-1-carboxylate 95+%
5g
$ 882.00

Crysdot
cis-tert-Butyl4-amino-3-fluoropiperidine-1-carboxylate 95+%
250mg
$ 118.00

Crysdot
cis-tert-Butyl4-amino-3-fluoropiperidine-1-carboxylate 95+%
1g
$ 360.00

Chemenu
tert-butylcis-4-amino-3-fluoropiperidine-1-carboxylate 97%
5g
$ 990.00

Chemenu
tert-butylcis-4-amino-3-fluoropiperidine-1-carboxylate 97%
10g
$ 1650.00

Chemenu
tert-butylcis-4-amino-3-fluoropiperidine-1-carboxylate 97%
1g
$ 330.00

Biosynth Carbosynth
cis-1,1-Dimethylethyl 4-amino-3-fluoro-1-piperidinecarboxylate
100 mg
$ 150.00

Total 38 raw suppliers

Chemical Property of Tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate

Chemical Property:

Vapor Pressure:0.003mmHg at 25°C
Refractive Index:1.481
Boiling Point:285.587 °C at 760 mmHg
PKA:8.88±0.40(Predicted)
Flash Point:126.519 °C
PSA：49.77000
Density:1.115 g/cm³
LogP:1.26410
Storage Temp.:2-8°C(protect from light)
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:218.14305602
Heavy Atom Count:15
Complexity:240

Purity/Quality:

99%, ^*data from raw suppliers

rel-tert-Butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(C(C1)F)N
Isomeric SMILES:CC(C)(C)OC(=O)N1CC[C@@H]([C@@H](C1)F)N

Technology Process of Tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate

There total 44 articles about Tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 907572-24-1,211108-52-0,211108-53-1
tert-butyl (3S,4R)-4-(benzylamino)-3-fluoro-piperidine-1-carboxylate

: 907544-20-1,577691-56-6
(3S,4R)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; at 50 ℃; for 1h;

Reference yield: 100.0%

: 211108-52-0,211108-53-1
trans-4-benzylamino-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester

: 577691-56-6
trans-4-amino-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; at 50 ℃; for 1h;

Reference yield: 99.0%

: 907572-28-5,211108-52-0,211108-53-1
tert-butyl-(3R,4S)-4-(benzylamino)-3-fluoro-piperidine-1-carboxylate

: 907544-17-6,577691-56-6
tert-butyl (3R,4S)-4-amino-3-fluoropiperidine-1-carboxylate

Guidance literature:: tert-butyl-(3R,4S)-4-(benzylamino)-3-fluoro-piperidine-1-carboxylate; With ammonium formate; In ethanol; water; at 20 ℃; for 0.0833333h; Inert atmosphere;

With palladium 10% on activated carbon; In ethanol; water; for 1h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2015.05.034