tert-butyl (3R,4R)-4-aMino-3-fluoropiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (3R,4R)-4-aMino-3-fluoropiperidine-1-carboxylate
• CAS No.: 1260612-08-5
• Molecular Formula: C10H19FN2O2
• Molecular Weight: 218.271
• Mol file: 1260612-08-5.mol

Synonyms:tert-butyl (3R,4R)-4-aMino-3-fluoropiperidine-1-carboxylate

Chemical Property of tert-butyl (3R,4R)-4-aMino-3-fluoropiperidine-1-carboxylate

Chemical Property:

• Boiling Point: 285.6±40.0 °C(Predicted)
• PKA: 8.88±0.40(Predicted)
• PSA: 55.56000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 1.93080
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (3R,4R)-4-aMino-3-fluoropiperidine-1-carboxylate

There total 12 articles about tert-butyl (3R,4R)-4-aMino-3-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(3R,4R)-tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate (211108-52-0,211108-53-1) → (3R,4R)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate (1260612-08-5,577691-56-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 16h;

Reference yield:

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate (211108-50-8) → (3S,4R)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate (907544-20-1,577691-56-6) + (3R,4R)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate (1260612-08-5,577691-56-6) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7)

Guidance literature:

With sodium tetraborate decahydrate; pyridoxal 5'-phosphate; Codexis ATA-303 transaminase; isopropylamine; In water; dimethyl sulfoxide; at 20 - 45 ℃; for 24h; pH=10.5; pH-value; enantioselective reaction; Inert atmosphere; Enzymatic reaction;

DOI:10.1021/acs.joc.9b00569

Reference yield:

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate (211108-50-8) → (3S,4R)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate (907544-20-1,577691-56-6) + (3R,4R)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate (1260612-08-5,577691-56-6)

Guidance literature:

With sodium tetraborate decahydrate; pyridoxal 5'-phosphate; Codexis ATA-303 transaminase; isopropylamine; In water; dimethyl sulfoxide; at 20 - 45 ℃; for 24h; pH=10.5; Overall yield = 66 %; Overall yield = 7.52 g; enantioselective reaction; Inert atmosphere; Enzymatic reaction;

DOI:10.1021/acs.joc.9b00569

upstream raw materials:

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-fluoro-4-((methylsulfonyl)oxy)piperidine-1-carboxylate

tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate

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