N-{2-[5-(4-methyl-3-chlorophenylamino)-[1,2,4]thiadiazol-3-yl]-1-methylethyl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine

Base Information

• Chemical Name: N-{2-[5-(4-methyl-3-chlorophenylamino)-[1,2,4]thiadiazol-3-yl]-1-methylethyl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine
• CAS No.: 1371630-57-7
• Molecular Formula: C₂₁H₃₂ClN₅S
• Molecular Weight: 422.038
• Mol file: 1371630-57-7.mol

Synonyms:

Chemical Property of N-{2-[5-(4-methyl-3-chlorophenylamino)-[1,2,4]thiadiazol-3-yl]-1-methylethyl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2-[5-(4-methyl-3-chlorophenylamino)-[1,2,4]thiadiazol-3-yl]-1-methylethyl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine

There total 3 articles about N-{2-[5-(4-methyl-3-chlorophenylamino)-[1,2,4]thiadiazol-3-yl]-1-methylethyl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H12ClN3OS (443111-03-3) → N-{2-[5-(4-methyl-3-chlorophenylamino)-[1,2,4]thiadiazol-3-yl]-1-methylethyl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine (1371630-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / 40 - 50 °C

With sodium tetrahydroborate; In methanol;

DOI:10.1134/S0012500812110031

Reference yield:

2-chloro-4-isothiocyanato-1-methyl-benzene (19241-37-3) → N-{2-[5-(4-methyl-3-chlorophenylamino)-[1,2,4]thiadiazol-3-yl]-1-methylethyl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine (1371630-57-7)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / acetonitrile / Reflux

2: methanol / 24 h / 20 °C

3: sodium tetrahydroborate; methanol / 50 °C

With methanol; sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; acetonitrile;

Reference yield:

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE (36768-62-4) → N-{2-[5-(4-methyl-3-chlorophenylamino)-[1,2,4]thiadiazol-3-yl]-1-methylethyl}-(2,2,6,6-tetramethylpiperidine-4-yl)-amine (1371630-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / 40 - 50 °C

With sodium tetrahydroborate; In methanol;

DOI:10.1134/S0012500812110031

upstream raw materials:

C₁₂H₁₂ClN₃OS

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE

2-chloro-4-isothiocyanato-1-methyl-benzene

Downstream raw materials:

N-{2'-[5-(3-chloro-4-methylphenylamino)-1,2,4-thiadiazol-3-yl]-1'-methylethyl}-(2'',2'',6'',6''-tetramethylpiperidin-4''-yl)aminodocosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid amide