Fmoc-Thr(tBu)-NHBn

Base Information

Chemical Name:Fmoc-Thr(tBu)-NHBn
CAS No.:929294-62-2
Molecular Formula:C₃₀H₃₄N₂O₄
Molecular Weight:486.611
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Fmoc-Thr(tBu)-NHBn

Chemical Property:

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Technology Process of Fmoc-Thr(tBu)-NHBn

There total 1 articles about Fmoc-Thr(tBu)-NHBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

: 100-46-9
benzylamine

: 929294-62-2
Fmoc-Thr(tBu)-NHBn

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/j.bmcl.2006.10.099

Reference yield:

: 929294-62-2
Fmoc-Thr(tBu)-NHBn

: 817167-11-6
NH₂-Thr(t-Bu)-NHBn

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ja207133t

Reference yield:

: 929294-62-2
Fmoc-Thr(tBu)-NHBn

: 1349173-05-2
Ac-Phe-Thr-NHBn

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / Cooling with ice

2.2: 0.5 h / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

5.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere; Cooling with ice

With triethylsilane; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja207133t