Fmoc-Thr(tBu)-NHBn

Base Information

• Chemical Name: Fmoc-Thr(tBu)-NHBn
• CAS No.: 929294-62-2
• Molecular Formula: C₃₀H₃₄N₂O₄
• Molecular Weight: 486.611
• Mol file: 929294-62-2.mol

Synonyms:

Chemical Property of Fmoc-Thr(tBu)-NHBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fmoc-Thr(tBu)-NHBn

There total 1 articles about Fmoc-Thr(tBu)-NHBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + benzylamine (100-46-9) → Fmoc-Thr(tBu)-NHBn (929294-62-2)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1016/j.bmcl.2006.10.099

Reference yield:

Fmoc-Thr(tBu)-NHBn (929294-62-2) → NH2-Thr(t-Bu)-NHBn (817167-11-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ja207133t

Reference yield:

Fmoc-Thr(tBu)-NHBn (929294-62-2) → Ac-Phe-Thr-NHBn (1349173-05-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / Cooling with ice

2.2: 0.5 h / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

5.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere; Cooling with ice

With triethylsilane; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja207133t

upstream raw materials:

Fmoc-Thr(tBu)-OH

benzylamine

Downstream raw materials:

Fmoc-Thr-NHBn

Fmoc-Thr(CO₂-nitrophenyl)-NHBn

NH₂-Thr(t-Bu)-NHBn

Ac-Phe-Thr-NHBn