(S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

Base Information

Chemical Name:(S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester
CAS No.:105590-82-7
Molecular Formula:C₃₉H₅₃N₅O₁₀
Molecular Weight:751.877
Hs Code.:

(S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

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Chemical Property of (S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

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Technology Process of (S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

There total 2 articles about (S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 71890-87-4
N-phenylmethoxycarbonyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanine

: 41089-47-8
L-glutamic acid α-methyl γ-benzyl diester hydrochloride

: 105590-82-7
(S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; 1.) 5 min; 2.) PhMe, RT;

Reference yield:

: 1676-73-9,25014-27-1
L-glutamic acid γ-benzyl ester

: 105590-82-7
(S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / 2.) HCl / 1.) THF, H₂O, ether, RT, 3 d; 2.) ether

2: 41 percent / 1.) triethylamine; 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 1.) 5 min; 2.) PhMe, RT

With hydrogenchloride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine;

Reference yield:

: 105590-82-7
(S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 1-methyl ester

: 105590-98-5
dimethyl N-(4'-chlorobenzoyl)-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / methanol / 4.2 kg cm^-2

2: tetrahydrofuran; diethyl ether

3: 47 percent / tetrahydrofuran / 96 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;