L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, dimethyl ester

Base Information

Chemical Name:L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, dimethyl ester
CAS No.:105590-98-5
Molecular Formula:C₃₂H₄₆ClN₅O₉
Molecular Weight:680.198
Hs Code.:
Mol file:105590-98-5.mol

Synonyms:

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Chemical Property of L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, dimethyl ester

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, dimethyl ester

There total 12 articles about L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 21368-28-5
4-chlorobenzoyl azide

: 105590-84-9
(S)-2-[2-Methyl-2-(2-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-propionylamino)-propionylamino]-pentanedioic acid dimethyl ester

: 105590-98-5
dimethyl N-(4'-chlorobenzoyl)-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-glutamate

Guidance literature:: In tetrahydrofuran; for 96h; Ambient temperature;

Reference yield:

: 71890-87-4
N-phenylmethoxycarbonyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanine

: 105590-98-5
dimethyl N-(4'-chlorobenzoyl)-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / 1.) triethylamine; 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 1.) 5 min; 2.) PhMe, RT

2: H₂ / 5percent Pd/C / methanol / 4.2 kg cm^-2

3: tetrahydrofuran; diethyl ether

4: 47 percent / tetrahydrofuran / 96 h / Ambient temperature

With hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;

Reference yield:

: 41089-47-8
L-glutamic acid α-methyl γ-benzyl diester hydrochloride

: 105590-98-5
dimethyl N-(4'-chlorobenzoyl)-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / 1.) triethylamine; 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 1.) 5 min; 2.) PhMe, RT

2: H₂ / 5percent Pd/C / methanol / 4.2 kg cm^-2

3: tetrahydrofuran; diethyl ether

4: 47 percent / tetrahydrofuran / 96 h / Ambient temperature

With hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;