3,5-DI-TERT-BUTYL-4-HYDROXYBENZENEPROPANOYL CHLORIDE

Base Information

• Chemical Name: 3,5-DI-TERT-BUTYL-4-HYDROXYBENZENEPROPANOYL CHLORIDE
• CAS No.: 3062-64-4
• Molecular Formula: C17H25 Cl O2
• Molecular Weight: 296.837
• Hs Code.: 2918199090
• Mol file: 3062-64-4.mol

Synonyms:Hydrocinnamoylchloride, 3,5-di-tert-butyl-4-hydroxy- (7CI,8CI);3,5-Di-tert-butyl-4-hydroxybenzenepropanoyl chloride;3,5-Di-tert-butyl-4-hydroxyphenylpropionyl chloride;3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid chloride;3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionyl chloride;3-(3',5'-Di-tert-butyl-4'-hydroxyphenyl)propionyl chloride

Chemical Property of 3,5-DI-TERT-BUTYL-4-HYDROXYBENZENEPROPANOYL CHLORIDE

Chemical Property:

• Vapor Pressure: 2.22E-05mmHg at 25°C
• Boiling Point: 350.1oC at 760 mmHg
• Flash Point: 165.5oC
• PSA: 37.30000
• Density: 1.063
• LogP: 4.68520

Purity/Quality:

98%Min ^*data from raw suppliers

3,5-Bis(tert-butyl)-4-hydroxybenzene-propanoyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DI-TERT-BUTYL-4-HYDROXYBENZENEPROPANOYL CHLORIDE

There total 2 articles about 3,5-DI-TERT-BUTYL-4-HYDROXYBENZENEPROPANOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-di-tert-butyl-4-hydroxycinnamic acid (95602-92-9) → 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionic acid chloride (3062-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C / 2585.81 Torr

2: thionyl chloride; DMF / toluene; CH₂Cl₂ / 2 h / 20 °C

With thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In ethanol; dichloromethane; toluene; 1: Catalytic hydrogenation / 2: Chlorination;

DOI:10.1021/jm990945v

Reference yield:

2,6-di-tert-butylphenol (128-39-2) + acrylonitrile (107-13-1,25014-41-9) → 4-chlorobenzedsulfonamide + 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionic acid chloride (3062-64-4)

Guidance literature:

Reference yield: 75.1%

2,2'-bis(n-octylthio)diethylamine + 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionic acid chloride (3062-64-4) → C37H67NO2S2

Guidance literature:

With ethylamine; at 0 - 20 ℃;

upstream raw materials:

3,5-di-tert-butyl-4-hydroxycinnamic acid

2,6-di-tert-butylphenol

acrylonitrile

Downstream raw materials:

5,11,17,23-Tetra-tert.-butyl-25,26,27,28-tetrakis-(4'-hydroxy-3,5-di-tert.-butylphenylpropionyl)-calix<4>aren

3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanamide

γ-(4-hydroxy-3,5-di-tert-butylphenyl)propylamine

1-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-propyl]-3-hydroxy-2-methyl-1H-pyridin-4-one