Methyl 2-broMo-3-cyclohexyl-1-Methyl-1H-indole-6-carboxylate

Base Information

• Chemical Name: Methyl 2-broMo-3-cyclohexyl-1-Methyl-1H-indole-6-carboxylate
• CAS No.: 494799-22-3
• Molecular Formula: C17H20 Br N O2
• Molecular Weight: 350.25000
• Hs Code.: 2933990090
• Mol file: 494799-22-3.mol

Synonyms:Methyl2-bromo-3-cyclohexyl-1-methyl-6-indolecarboxylate

Chemical Property of Methyl 2-broMo-3-cyclohexyl-1-Methyl-1H-indole-6-carboxylate

Chemical Property:

• PSA: 31.23000
• LogP: 4.77510
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-broMo-3-cyclohexyl-1-Methyl-1H-indole-6-carboxylate

There total 8 articles about Methyl 2-broMo-3-cyclohexyl-1-Methyl-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-cyclohexyl-1-methylindole-6-carboxylic acid methyl ester (494799-21-2) → 2-bromo-3-cyclohexyl-1-methylindole-6-carboxylic acid methyl ester (494799-22-3)

Guidance literature:

With pyridinium hydrobromide perbromide; In tetrahydrofuran; chloroform; for 1h; cooling;

DOI:10.1016/j.bmcl.2006.07.074

Reference yield: 76.0%

→ 2-bromo-3-cyclohexyl-1-methylindole-6-carboxylic acid methyl ester (494799-22-3)

Guidance literature:

Reference yield:

3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid (494799-16-5) → 2-bromo-3-cyclohexyl-1-methylindole-6-carboxylic acid methyl ester (494799-22-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: H₂ / Pd(OH)2/C / methanol; tetrahydrofuran / 24 h / 20 °C / 2844.31 Torr

2.1: 21.90 g / K₂CO₃ / dimethylformamide / 20 °C

3.1: NaH / dimethylformamide / 1 h / 0 °C

3.2: 86 percent / dimethylformamide / 18 h / 20 °C

4.1: 76 percent / pyridinium bromide perbromide / CHCl₃; tetrahydrofuran / 1 h / cooling

With hydrogen; pyridinium hydrobromide perbromide; sodium hydride; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.07.074

upstream raw materials:

3-cyclohexyl-1-methylindole-6-carboxylic acid methyl ester

methyl 3-cyclohexyl-1H-indole-6-carboxylate

3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid

3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid

Downstream raw materials:

3-cyclohexyl-2-furan-3-yl-1-methyl-1H-indole-6-carboxylic acid

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