BENZENEBUTANOL, DELTA-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-, (DELTAS)-

Base Information

• Chemical Name: BENZENEBUTANOL, DELTA-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-, (DELTAS)-
• CAS No.: 241818-03-1
• Molecular Formula: C16H28 O2 Si
• Molecular Weight: 280.481
• Mol file: 241818-03-1.mol

Synonyms:BENZENEBUTANOL, DELTA-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-, (DELTAS)-;4-(tert-butyldimethylsilyloxy)-4-phenylbutan-1-ol

Chemical Property of BENZENEBUTANOL, DELTA-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-, (DELTAS)-

Chemical Property:

• Boiling Point: 346.4±35.0 °C(Predicted)
• PKA: 15.04±0.10(Predicted)
• PSA: 29.46000
• Density: 0.951±0.06 g/cm3(Predicted)
• LogP: 4.52200
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-((tert-Butyldimethylsilyl)-oxy)-4-phenylbutan-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZENEBUTANOL, DELTA-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-, (DELTAS)-

There total 5 articles about BENZENEBUTANOL, DELTA-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-, (DELTAS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Acetic acid (S)-4-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl ester (241818-02-0) → (S)-4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butan-1-ol (241818-03-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1039/c39910000799

Reference yield: 74.0%

C22H42O2Si2 (1056016-27-3) → (S)-4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butan-1-ol (241818-03-1)

Guidance literature:

With pyridinium hydrobromide perbromide; In methanol; at 0 ℃;

DOI:10.1016/j.tetlet.2008.06.072

Reference yield:

(S)-4-hydroxy-4-phenylbutyl acetate (139527-16-5) → (S)-4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butan-1-ol (241818-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / imidazole / dimethylformamide

2: 86 percent / LiAlH₄ / diethyl ether

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1039/c39910000799

upstream raw materials:

Acetic acid (S)-4-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl ester

(S)-4-hydroxy-4-phenylbutyl acetate

(S)-(-)-1-Phenylbutane-1,4-diol

tert-butyldimethylsilyl chloride

Downstream raw materials:

Toluene-4-sulfonic acid (S)-4-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl ester

(S)-1-phenylbutan-1-ol

tert-Butyl-dimethyl-((S)-1-phenyl-butoxy)-silane