1-Phenethylpiperidin-4-amine hydrochloride

Base Information

• Chemical Name: 1-Phenethylpiperidin-4-amine hydrochloride
• CAS No.: 127285-07-8
• Molecular Formula: C₁₃H₂₀N₂*ClH
• Molecular Weight: 240.776
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40508656
• Mol file: 127285-07-8.mol

Synonyms:127285-07-8;1-Phenethylpiperidin-4-amine hydrochloride;4-AMINO-1-N-PHENYLETHYLPIPERIDINE HCL;1-Phenethyl-piperidin-4-ylamine hydrochloride;1-(2-phenylethyl)piperidin-4-amine hydrochloride;4-Amino-1-N-phenylethylpiperidine hydrochloride;1-(2-phenylethyl)piperidin-4-amine;hydrochloride;[1-(2-phenylethyl)piperidin-4-yl]azanium;chloride;4-Piperidinamine, 1-(2-phenylethyl)-, hydrochloride (1:1);1-Phenethylpiperidin-4-aminehydrochloride;SCHEMBL8788285;DTXSID40508656;LTHSVKBFWOSWKK-UHFFFAOYSA-N;CFA28507;MFCD09877749;AKOS015909578;AS-35936;4-amino-1-phenethyl-piperidine hydrochloride;CS-0171327;FT-0650926;1-PhenEthyl-piperidin-4-ylaminehydrochloride HCL;A805675;4-Piperidinamine,1-(2-phenylethyl)-,hydrochloride(1:1);4-amino-1-N-phenylethylpiperidine hydrochloride, AldrichCPR;1-(2-Phenylethyl)piperidin-4-amine--hydrogen chloride (1/1)

Chemical Property of 1-Phenethylpiperidin-4-amine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000809mmHg at 25°C
• Boiling Point: 305.7 °C at 760 mmHg
• Flash Point: 127.6 °C
• PSA: 29.26000
• LogP: 3.09240
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 240.1393264
• Heavy Atom Count: 16
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

1-Phenethylpiperidin-4-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1N)CCC2=CC=CC=C2.Cl

Technology Process of 1-Phenethylpiperidin-4-amine hydrochloride

There total 7 articles about 1-Phenethylpiperidin-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-phenethylpiperidin-4-one oxime (79278-71-0) → 1-phenethylpiperidin-4-amine hydrochloride (127285-07-8)

Guidance literature:

1-phenethylpiperidin-4-one oxime; With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Reflux;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1002/cphc.202100165

Reference yield: 64.0%

→ 1-phenethyl-4-aminopiperidine dihydrochloride (127285-07-8)

Guidance literature:

Reference yield:

4-amino-1-benzylpiperidine (50541-93-0) → 1-phenethylpiperidin-4-amine hydrochloride (127285-07-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / CH₂Cl₂ / 18 h / Ambient temperature

2: 97 percent / H₂ / 10 percent Pd/C / methanol / 18 h / 2585.74 Torr

3: ethyldiisopropylamine / dimethylformamide / 42 h / Ambient temperature

4: HCl / methanol / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm991029k

upstream raw materials:

4-amino-1-benzylpiperidine

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl (1-benzylpiperidin-4-yl)carbamate

1-phenethylpiperidin-4-one oxime

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