(+/-)-12α-methoxycarbonylestrone

Base Information

Chemical Name:(+/-)-12α-methoxycarbonylestrone
CAS No.:111426-60-9
Molecular Formula:C₂₀H₂₄O₄
Molecular Weight:328.408
Hs Code.:

Synonyms:

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Chemical Property of (+/-)-12α-methoxycarbonylestrone

Chemical Property:

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Technology Process of (+/-)-12α-methoxycarbonylestrone

There total 22 articles about (+/-)-12α-methoxycarbonylestrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 765-69-5
2-Methylcyclopentane-1,3-dione

: 111426-60-9,111426-61-0
(+/-)-12β-methoxycarbonylestrone

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / 5 percent triethylamine / ethyl acetate / 4.5 h / Heating

2: 90 percent / methanesulfonic acid / CH₂Cl₂ / 0.33 h

3: 95 percent / NaBH₄ / benzene; methanol / 0.25 h / 0 °C

4: 99 percent / H₂ / 10 percent Pd/C / benzene

5: 99 percent / 2 N KOH / methanol / 2 h / Heating

6: 90 percent / Na / liquid ammonia; tetrahydrofuran; various solvent(s) / 0.33 h

7: 93 percent / 8 N H₂CrO₄ / CH₂Cl₂; acetone / 0.42 h

8: NaI, chlorotrimethylsilane / acetonitrile / 4 h / 60 °C

9: 10 percent HCl / 0.17 h / 60 °C

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; chloro-trimethyl-silane; hydrogen; sodium; chromic acid; triethylamine; sodium iodide; palladium on activated charcoal; methanesulfonic acid; In tetrahydrofuran; methanol; dichloromethane; ammonia; ethyl acetate; acetone; acetonitrile; benzene;
DOI:10.1248/cpb.35.585

Reference yield:

: 80114-83-6,80183-68-2,111467-67-5,111467-68-6
(+/-)-12β-methoxycarbonyl-3-methoxyestra-1,3,5(10),8,14-pentaen-17-one

: 111426-60-9,111426-61-0
(+/-)-12β-methoxycarbonylestrone

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / NaBH₄ / benzene; methanol / 0.25 h / 0 °C

2: 99 percent / H₂ / 10 percent Pd/C / benzene

3: 99 percent / 2 N KOH / methanol / 2 h / Heating

4: 90 percent / Na / liquid ammonia; tetrahydrofuran; various solvent(s) / 0.33 h

5: 93 percent / 8 N H₂CrO₄ / CH₂Cl₂; acetone / 0.42 h

6: NaI, chlorotrimethylsilane / acetonitrile / 4 h / 60 °C

7: 10 percent HCl / 0.17 h / 60 °C

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; chloro-trimethyl-silane; hydrogen; sodium; chromic acid; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ammonia; acetone; acetonitrile; benzene;
DOI:10.1248/cpb.35.585

Reference yield:

: 80114-82-5
2-<6-(3-methoxyphenyl)-1-methoxycarbonyl-3-oxohexyl>-2-methylcyclopentane-1,3-dione

: 111426-60-9,111426-61-0
(+/-)-12β-methoxycarbonylestrone

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / methanesulfonic acid / CH₂Cl₂ / 0.33 h

2: 95 percent / NaBH₄ / benzene; methanol / 0.25 h / 0 °C

3: 99 percent / H₂ / 10 percent Pd/C / benzene

4: 99 percent / 2 N KOH / methanol / 2 h / Heating

5: 90 percent / Na / liquid ammonia; tetrahydrofuran; various solvent(s) / 0.33 h

6: 93 percent / 8 N H₂CrO₄ / CH₂Cl₂; acetone / 0.42 h

7: NaI, chlorotrimethylsilane / acetonitrile / 4 h / 60 °C

8: 10 percent HCl / 0.17 h / 60 °C

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; chloro-trimethyl-silane; hydrogen; sodium; chromic acid; sodium iodide; palladium on activated charcoal; methanesulfonic acid; In tetrahydrofuran; methanol; dichloromethane; ammonia; acetone; acetonitrile; benzene;
DOI:10.1248/cpb.35.585