3-fluoro-4-(methoxymethyl)aniline

Base Information

• Chemical Name: 3-fluoro-4-(methoxymethyl)aniline
• CAS No.: 1341785-86-1
• Molecular Formula: C₈H₁₀FNO
• Molecular Weight: 155.172
• Mol file: 1341785-86-1.mol

Synonyms:

Chemical Property of 3-fluoro-4-(methoxymethyl)aniline

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

3-Fluoro-4-(methoxymethyl)aniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-4-(methoxymethyl)aniline

There total 3 articles about 3-fluoro-4-(methoxymethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-1-(methoxymethyl)-4-nitrobenzene → 3-fluoro-4-(methoxymethyl)aniline (1341785-86-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 18h;

Reference yield:

(2-fluoro-4-nitrophenyl)methanol (660432-43-9) → 3-fluoro-4-(methoxymethyl)aniline (1341785-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium hydroxide; In methanol; dimethyl sulfoxide;

Reference yield:

2-fluoro-4-nitro-benzoic acid methyl ester (392-09-6) → 3-fluoro-4-(methoxymethyl)aniline (1341785-86-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / 4.5 h / 20 °C

2: potassium hydroxide / dimethyl sulfoxide / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; potassium hydroxide; In methanol; dimethyl sulfoxide;

upstream raw materials:

(2-fluoro-4-nitrophenyl)methanol

2-fluoro-4-nitro-benzoic acid methyl ester

Refernces

• 1、 -. "NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF". Paragraph 1339-1341. . Retrieved 2018/02/28.