{(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

Base Information

Chemical Name:{(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester
CAS No.:342897-28-3
Molecular Formula:C₂₇H₃₉N₅O₈
Molecular Weight:561.635
Hs Code.:

{(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

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Chemical Property of {(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

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Technology Process of {(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

There total 8 articles about {(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181827-47-4
(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carboxylic acid

: 5-((1R,2S)-2-Amino-1-hydroxy-3-methyl-butyl)-3-(4-methoxy-2-methyl-phenyl)-3H-[1,3,4]oxadiazol-2-one; compound with toluene-4-sulfonic acid

: 342897-28-3
{(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 7h;
DOI:10.1016/S0968-0896(01)00007-4

Reference yield:

: 250165-20-9
tert-butoxy-N-[(1S)-1-((2R)-oxiran-2-yl)-2-methylpropyl]carboxamide

: 342897-28-3
{(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 59 percent / Li₂CO₃ / dimethylformamide / 17 h / 100 °C

2: 90 percent / 10-camphorsulfonic acid / dimethylformamide / 2 h / 20 °C

3: 8.74 g / potassium carbonate / methanol / 3 h / 20 °C

4: 73 percent / NaIO₄; RuCl₃*nH₂O / CCl₄; acetonitrile; H₂O

5: 82 percent / N-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; N-methylmorpholine / dimethylformamide / 7 h / 20 °C

6: 59 percent / triethylamine / tetrahydrofuran / 15 h / 80 °C

7: ethanol / 80 °C

8: N-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; N-methylmorpholine / dimethylformamide / 7 h / 20 °C

With 4-methyl-morpholine; ruthenium trichloride; sodium periodate; (1S)-10-camphorsulfonic acid; lithium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(01)00007-4

Reference yield:

: 342897-05-6
tert-butyl (4S,5R)-5-(hydroxymethyl)-2,2-dimethyl-4-(methylethyl)-1,3-oxazolidine-3-carboxylate

: 342897-28-3
{(S)-1-[(S)-2-((S)-1-{(R)-Hydroxy-[4-(4-methoxy-2-methyl-phenyl)-5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl]-methyl}-2-methyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / NaIO₄; RuCl₃*nH₂O / CCl₄; acetonitrile; H₂O

2: 82 percent / N-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; N-methylmorpholine / dimethylformamide / 7 h / 20 °C

3: 59 percent / triethylamine / tetrahydrofuran / 15 h / 80 °C

4: ethanol / 80 °C

5: N-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; N-methylmorpholine / dimethylformamide / 7 h / 20 °C

With 4-methyl-morpholine; ruthenium trichloride; sodium periodate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(01)00007-4