Technology Process of 1-Methoxy-2-(2-tolyl)propan
There total 11 articles about 1-Methoxy-2-(2-tolyl)propan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
diethyl ether;
for 12h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) butyllithium, diisopropylamine, hexamethylphosphoric triamide (HMPT) / 1.) hexane, THF, rt, 30 min 2.) 90 min
2: 82 percent / LiAlH4 / diethyl ether / 1 h / Heating
3: 61 percent / NaH / diethyl ether / 12 h / Ambient temperature
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; sodium hydride; diisopropylamine;
In
diethyl ether;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 15 percent / diethyl ether / 96 h / 0 °C
2: 96 percent / 1 M diisobutylaluminiumhydride (DIBAL-H) / 1.) hexane, ether, -78 deg C, 4 h 2.) rt, 2 h
3: 55 percent / NaH / diethyl ether / 24 h / Ambient temperature
4: 1.) LiEt3BH 2.) 3 M NaOH, 30 percent H2O2 / 1.) THF, reflux, 4 h 2.) a) 0 deg C, b) 50 deg C, 2 h
5: 91 percent / bromine on Amberlyst A 26 / CH2Cl2 / 10 h / Ambient temperature
6: 35 percent / KOtBu / tetrahydrofuran / 16 h / -15 °C
7: benzene-d6 / 12 h / 70 °C
With
sodium hydroxide; bromine on Amberlyst A 26; potassium tert-butylate; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; lithium triethylborohydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; benzene-d6;
