N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide

Base Information

• Chemical Name: N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide
• CAS No.: 454219-15-9
• Molecular Formula: C₂₃H₃₄N₄O₄S
• Molecular Weight: 462.613
• Mol file: 454219-15-9.mol

Synonyms:

Chemical Property of N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide

There total 6 articles about N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,6S)-2,6-Dimethyl-morpholine-4-sulfonic acid (4-{2-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-pyridin-3-yl-ethylamino]-2-methyl-propyl}-phenyl)-amide → N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide (454219-15-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2004.03.089

Reference yield:

N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine (82408-64-8) → N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide (454219-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / diisopropylethylamine / dimethylsulfoxide / 48 h / 100 °C

2: 93 percent / ammonium formate; Pd/C / methanol

3: pyridine / 1,2-dichloro-ethane / -35 - 60 °C

4: tetrabutylammonium fluoride / tetrahydrofuran

With pyridine; palladium on activated charcoal; tetrabutyl ammonium fluoride; ammonium formate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2004.03.089

Reference yield:

(R)-toluene-4-sulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl ester (364080-73-9) → N-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]2-methylpropyl]phenyl]-2,6-dimethyl-,(2R,6S)-4-morpholinesulfonamide (454219-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / diisopropylethylamine / dimethylsulfoxide / 48 h / 100 °C

2: 93 percent / ammonium formate; Pd/C / methanol

3: pyridine / 1,2-dichloro-ethane / -35 - 60 °C

4: tetrabutylammonium fluoride / tetrahydrofuran

With pyridine; palladium on activated charcoal; tetrabutyl ammonium fluoride; ammonium formate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2004.03.089

upstream raw materials:

N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine

(R)-toluene-4-sulfonic acid 2-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl ester

4-{2(R)-[2-(tert-butyl-dimethyl-silanyloxy)-2-pyridin-3-yl-ethylamino]-2-methyl-propyl}-phenylamine

[2(R)-(tert-butyl-dimethyl-silanyloxy)-2-(6-chloro-pyridin-3-yl)-ethyl]-[1,1-dimethyl-2-(4-nitro-phenyl)-ethyl]-amine