8-BROMOQUINOLINE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 8-BROMOQUINOLINE-4-CARBOXYLIC ACID
• CAS No.: 121490-67-3
• Molecular Formula: C₁₀H₆BrNO₂
• Molecular Weight: 252.067
• Hs Code.: 2933499090
• Mol file: 121490-67-3.mol

Synonyms:8-Bromo-4-quinolinecarboxylicacid;8-Bromoquinoline-4-carboxylic acid;

Chemical Property of 8-BROMOQUINOLINE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 3.21E-07mmHg at 25°C
• Refractive Index: 1.709
• Boiling Point: 403.1 °C at 760 mmHg
• PKA: 2.83±0.30(Predicted)
• Flash Point: 197.6 °C
• PSA: 50.19000
• Density: 1.732 g/cm³
• LogP: 2.69550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Bromoquinoline-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-BROMOQUINOLINE-4-CARBOXYLIC ACID is a useful research chemical.

Technology Process of 8-BROMOQUINOLINE-4-CARBOXYLIC ACID

There total 6 articles about 8-BROMOQUINOLINE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

8-bromo-quinoline-4-carbaldehyde (898391-87-2) → 8-bromoquinoline-4-carboxylic acid (121490-67-3)

Guidance literature:

8-bromo-quinoline-4-carbaldehyde; With sodium chlorite; sodium phosphate; In tetrahydrofuran; water; at 5 - 10 ℃; for 2h;

With sodium thiosulfate; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 90.0%

→ 8-bromoquinoline-4-carboxylic acid (121490-67-3)

Guidance literature:

In water; at 200 ℃; for 4h;

Reference yield:

8-bromoquinoline-2,4-dicarboxylic acid → 8-bromoquinoline-4-carboxylic acid (121490-67-3)

Guidance literature:

In water; at 205 ℃; for 2h; Autoclave;

DOI:10.1021/ml300410d

upstream raw materials:

7-bromoisatin

8-bromo-4-methylquinoline

8-bromo-quinoline-4-carbaldehyde

2-bromoaniline

Downstream raw materials:

8-bromo-N-methyl-quinoline-4-carboxamide

(S)-N-methyl-8-(1-((2'-methyl-4',6'-dideutero-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide

Refernces

• 1、 -. "Quinoline formamide compound as well as preparation method and application thereof". Paragraph 0130-0132; 0136-0138; 0184-0186; 0190-0192. . Retrieved 2020/11/25.
• 2、 -. "NOVEL FAP INHIBITORS". Page/Page column 55. . Retrieved 2013/07/31.