C₅₂H₄₆N₄O₂

Base Information

• Chemical Name: C₅₂H₄₆N₄O₂
• CAS No.: 1333325-18-0
• Molecular Formula: C₅₂H₄₆N₄O₂
• Molecular Weight: 758.963
• Mol file: 1333325-18-0.mol

Synonyms:

Chemical Property of C₅₂H₄₆N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₂H₄₆N₄O₂

There total 9 articles about C₅₂H₄₆N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,6-dibromophenylazo)pyrrolidine (338730-94-2) → C52H46N4O2 (1333325-18-0)

Guidance literature:

Multi-step reaction with 7 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 48 h / Inert atmosphere; Reflux

2: iodine / dichloromethane / 20 h / Inert atmosphere; Reflux

3: hydrogen iodide / water / 20 h / 120 °C / Inert atmosphere

4: triethylamine / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 10 °C / Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

7: caesium carbonate / N,N-dimethyl-formamide / 18 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrogen iodide; iodine; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Stille coupling / 5: Sonogashira coupling;

DOI:10.1039/c1cc11209k

Reference yield:

C22H26N2OSn (1333325-09-9) → C52H46N4O2 (1333325-18-0)

Guidance literature:

Multi-step reaction with 7 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 48 h / Inert atmosphere; Reflux

2: iodine / dichloromethane / 20 h / Inert atmosphere; Reflux

3: hydrogen iodide / water / 20 h / 120 °C / Inert atmosphere

4: triethylamine / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 10 °C / Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

7: caesium carbonate / N,N-dimethyl-formamide / 18 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrogen iodide; iodine; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Stille coupling / 5: Sonogashira coupling;

DOI:10.1039/c1cc11209k

Reference yield:

C42H33IN4O2 → C52H46N4O2 (1333325-18-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 16 h / 10 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 18 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 2: Sonogashira coupling;

DOI:10.1039/c1cc11209k

upstream raw materials:

1-(2,6-dibromophenylazo)pyrrolidine

C₆₀H₇₄N₄O₂Si₂

C₂₂H₂₆N₂OSn

4-pentynyl-1-tosylate