ethyl (2S,3R)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate

Base Information

• Chemical Name: ethyl (2S,3R)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate
• CAS No.: 1009642-03-8
• Molecular Formula: C₂₁H₃₃NO₈
• Molecular Weight: 427.495
• Mol file: 1009642-03-8.mol

Synonyms:

Chemical Property of ethyl (2S,3R)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2S,3R)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate

There total 1 articles about ethyl (2S,3R)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl carbazate (4248-19-5) + ethyl 3-(4'-(2-methoxyethoxymethoxy)phenyl)prop-2-enoate (123994-66-1) + methyl iodide (74-88-4) → ethyl 2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate + ethyl (2S,3R)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate (1009642-03-8) + ethyl (2R,3S)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate (1009642-02-7)

Guidance literature:

tert-butyl carbazate; ethyl 3-(4'-(2-methoxyethoxymethoxy)phenyl)prop-2-enoate; With sodium hydroxide; hydroquinidine anthraquinone-1,4-diyl diether; tert-butylhypochlorite; K2; In propan-1-ol; water; for 19h;

methyl iodide; With sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 16h; Further stages. Title compound not separated from byproducts.;

DOI:10.1055/s-2007-990848

Reference yield:

ethyl (2S,3R)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate (1009642-03-8) + N-methyl-L-alanine methyl ester (35023-55-3) → Boc-(2S,3R)-β-MeO-Tyr(MEM)-N-Me-Ala-OMe

Guidance literature:

ethyl (2S,3R)-2-tert-butoxycarbonylamino-3-(4-(2-methoxyethoxymethoxy)phenyl)-3-methoxypropanoate; With lithium hydroxide; water; In tert-butyl alcohol; at 20 ℃; for 2h;

N-methyl-L-alanine methyl ester; With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Further stages.;

DOI:10.1055/s-2007-990848

upstream raw materials:

tert-butyl carbazate

ethyl 3-(4'-(2-methoxyethoxymethoxy)phenyl)prop-2-enoate

methyl iodide