2-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 2-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 359803-43-3
• Molecular Formula: C10H19 N3 O3
• Molecular Weight: 229.279
• Hs Code.: 2933990090
• Mol file: 359803-43-3.mol

Synonyms:2-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1,2-Pyrrolidinedicarboxylic acid,1-(1,1-dimethylethyl) ester,2-hydrazide;

Chemical Property of 2-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 1.8E-06mmHg at 25°C
• Boiling Point: 395.8oC at 760 mmHg
• Flash Point: 193.1oC
• PSA: 84.66000
• Density: 1.18g/cm3
• LogP: 1.40490
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Hydrazinocarbonyl-pyrrolidine-1-carboxylicacidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about 2-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-N-tert-butoxycarbonylproline methyl ester (145681-01-2) → tert-butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate (359803-43-3,1373959-74-0)

Guidance literature:

With hydrazine hydrate; In methanol; at 0 - 60 ℃; for 16h; Temperature;

Reference yield:

N-tert-butoxycarbonyl-proline (15761-39-4,59433-50-0) → tert-butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate (359803-43-3,1373959-74-0)

Guidance literature:

N-tert-butoxycarbonyl-proline; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at -15 ℃; for 0.583333h;

With hydrazine; In tetrahydrofuran; at 0 - 20 ℃; for 2.25h;

Reference yield:

methyl pyrrolidine-2-carboxylate (43041-12-9,52183-82-1,2577-48-2) → tert-butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate (359803-43-3,1373959-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 16.17 h / 0 - 20 °C

2: hydrazine hydrate / methanol / 16 h / 0 - 60 °C

With hydrazine hydrate; triethylamine; In methanol; acetonitrile;

upstream raw materials:

N-tert-butoxycarbonyl-proline

(+/-)-N-tert-butoxycarbonylproline methyl ester

methyl pyrrolidine-2-carboxylate

rac-Pro-OH

Downstream raw materials:

C₁₇H₂₂ClN₃O₄

tert-butyl 2-(2-((2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]-octane-2-carbonyl)hydrazinecarbonyl)pyrrolidine-1-carboxylate

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