5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)[3-(N-tert-butylaminocarbonyl)-1-propyloxy]phosphinylthymidine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)[3-(N-tert-butylaminocarbonyl)-1-propyloxy]phosphinylthymidine
• CAS No.: 471878-77-0
• Molecular Formula: C₄₅H₆₁N₄O₉P
• Molecular Weight: 832.974
• Mol file: 471878-77-0.mol

Synonyms:

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)[3-(N-tert-butylaminocarbonyl)-1-propyloxy]phosphinylthymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)[3-(N-tert-butylaminocarbonyl)-1-propyloxy]phosphinylthymidine

There total 2 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)[3-(N-tert-butylaminocarbonyl)-1-propyloxy]phosphinylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + O-[3-(N-tert-butylaminocarbonyl)-1-propyl]-N,N,N',N'-tetraisopropylphosphordiamidite (471878-60-1) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)[3-(N-tert-butylaminocarbonyl)-1-propyloxy]phosphinylthymidine (471878-77-0)

Guidance literature:

With 1H-tetrazole; In dichloromethane; at 25 ℃; for 3h;

DOI:10.1021/jo0258608

Reference yield:

N-tert-butyl-4-hydroxybutyramide (471878-58-7) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)[3-(N-tert-butylaminocarbonyl)-1-propyloxy]phosphinylthymidine (471878-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 g / benzene; acetonitrile / 2 h / 25 °C

2: 1H-tetrazole / CH₂Cl₂ / 3 h / 25 °C

With 1H-tetrazole; In dichloromethane; acetonitrile; benzene;

DOI:10.1021/jo0258608

upstream raw materials:

5'-O-(4-4'-dimethoxytrityl)thymidine

O-[3-(N-tert-butylaminocarbonyl)-1-propyl]-N,N,N',N'-tetraisopropylphosphordiamidite

N-tert-butyl-4-hydroxybutyramide