1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine

Base Information

• Chemical Name: 1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine
• CAS No.: 35808-40-3
• Molecular Formula: C7H9 N3
• Molecular Weight: 135.16600
• Hs Code.: 2933990090
• European Community (EC) Number: 889-383-0
• DSSTox Substance ID: DTXSID20501529
• Wikidata: Q82353960
• Mol file: 35808-40-3.mol

Synonyms:1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine;35808-40-3;1,2,3,4-Tetrahydro-Pyrido[2,3-B]Pyrazine;1H,2H,3H,4H-pyrido[2,3-b]pyrazine;tetrahydropyridopyrazine;SCHEMBL516458;F6170-0034;DTXSID20501529;HOFCYSNYAFJTSI-UHFFFAOYSA-N;MFCD08062758;AKOS006283987;CCG-322789;MB05240;DS-10637;A6239;CS-0019165;FT-0648553;EN300-99377;Z1198175971

Chemical Property of 1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 318.508oC at 760 mmHg
• Flash Point: 146.429oC
• PSA: 36.95000
• Density: 1.112g/cm3
• LogP: 1.19500
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 135.079647300
• Heavy Atom Count: 10
• Complexity: 115

Purity/Quality:

98%min ^*data from raw suppliers

1,2,3,4-Tetrahydropyrido[2,3-B]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC2=C(N1)C=CC=N2
• Uses: 1,2,3,4-Tetrahydropyrido[2,3-B]pyrazine can be used as SHP2 phosphatase inhibitors.

Technology Process of 1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine

There total 3 articles about 1,2,3,4-Tetrahydropyrido[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-azaquinoxaline (322-46-3) → pyrido[2,3-b]-1,2,3,4-tetrahydropyrazine (35808-40-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 24h;

DOI:10.1139/v82-400

Reference yield: 45.0%

2,3-Diaminopyridine (452-58-4) + ethylene glycol (107-21-1) → 5,6,7,8-tetrahydropyrido[2,3-b]pyrazine + pyrido[2,3-b]-1,2,3,4-tetrahydropyrazine (35808-40-3)

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tert-Amyl alcohol; at 130 ℃; for 5h; Overall yield = 77 %; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1039/c6cc05329g

Reference yield:

→ pyrido[2,3-b]-1,2,3,4-tetrahydropyrazine (35808-40-3)

Guidance literature:

Pyrido<2,3-b>pyrazin (1), LiAlH4, THF;

upstream raw materials:

5-azaquinoxaline

2,3-Diaminopyridine

ethylene glycol

Refernces

• 1、 Cosmao, Jean-Marie,Collignon, Noel,Queguiner, Guy. "Regioselectivite de l'hydrogenation catalitique de quelques pyridopyrazines". . p. 2785 - 2791. Retrieved 2007/10/02.