trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide

Base Information

• Chemical Name: trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide
• CAS No.: 117487-94-2
• Molecular Formula: C₁₆H₂₀N₄O₃S
• Molecular Weight: 348.426
• Mol file: 117487-94-2.mol

Synonyms:

Chemical Property of trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide

There total 1 articles about trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-Benzenesulfonyl-bicyclo[1.1.0]but-1-yl)-piperidin-1-yl-methanone (117487-83-9) → cis-1-Azido-N,N-pentamethylene-3-(phenylsulfonyl)cyclobutane-1-carboxamide (117488-02-5) + trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide (117487-94-2)

Guidance literature:

With N,N,N',N'-tetramethylguanidinium azide; In various solvent(s); at 80 - 90 ℃; for 3h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(00)80361-5

Reference yield:

trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide (117487-94-2) → (1-Amino-3-benzenesulfonyl-cyclobutyl)-piperidin-1-yl-methanone

Guidance literature:

With palladium on activated charcoal; ammonium formate; In methanol; at 50 ℃; for 5h;

Reference yield:

trans-1-azido-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide (117487-94-2) → trans-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxylamide

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium formate, 10percent Pd/C / methanol / 5 h / 50 °C

2: pyridine / CH₂Cl₂

With pyridine; palladium on activated charcoal; ammonium formate; In methanol; dichloromethane;

upstream raw materials:

(3-Benzenesulfonyl-bicyclo[1.1.0]but-1-yl)-piperidin-1-yl-methanone