C₁₉H₂₂N₂O₃

Base Information

Chemical Name:C₁₉H₂₂N₂O₃
CAS No.:1290137-28-8
Molecular Formula:C₁₉H₂₂N₂O₃
Molecular Weight:326.395
Hs Code.:

C<sub>19</sub>H<sub>22</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:

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Chemical Property of C₁₉H₂₂N₂O₃

Chemical Property:

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Technology Process of C₁₉H₂₂N₂O₃

There total 7 articles about C₁₉H₂₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290137-27-7
(1R,2S,4R,5R)-4-(benzyloxymethyl)bicyclo[3.1.0]hexan-2-ol

: 4330-20-5
N-3-benzoylthymine

: 1290137-28-8
C₁₉H₂₂N₂O₃

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;

(1R,2S,4R,5R)-4-(benzyloxymethyl)bicyclo[3.1.0]hexan-2-ol; N-3-benzoylthymine; In acetonitrile; at -40 - 20 ℃; Inert atmosphere;

With sodium hydroxide; In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201001473

Reference yield:

: 1146288-87-0
(1R,2S,4S)-2-(benzyloxymethyl)-4-hydroxycyclopentyl methanesulfonate

: 1290137-28-8
C₁₉H₂₂N₂O₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / Reflux

2.1: diethylzinc / hexane; dichloromethane / -10 - 0 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

3.2: -40 - 20 °C / Inert atmosphere

3.3: 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium tert-butylate; diethylzinc; triphenylphosphine; In hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.1: Simmons-Smith reaction / 3.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;
DOI:10.1002/ejoc.201001473

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1290137-28-8
C₁₉H₂₂N₂O₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: L-diisopinocampheylborane / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2.2: 4 h / 0 °C

3.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.2: oxone / 6 h / 0 °C

5.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / Reflux

6.1: diethylzinc / hexane; dichloromethane / -10 - 0 °C / Inert atmosphere

7.1: di-isopropyl azodicarboxylate; triphenylphosphine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

7.2: -40 - 20 °C / Inert atmosphere

7.3: 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium tert-butylate; diethylzinc; sodium hydride; triethylamine; 9-bora-bicyclo[3.3.1]nonane; triphenylphosphine; L-diisopinocampheylborane; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.1: Hydroboration reaction / 4.1: Hydroboration reaction / 6.1: Simmons-Smith reaction / 7.1: Mitsunobu reaction / 7.2: Mitsunobu reaction;
DOI:10.1002/ejoc.201001473