p-Nitrophenoxyamine

Base Information

• Chemical Name: p-Nitrophenoxyamine
• CAS No.: 33543-55-4
• Molecular Formula: C6H6N2O3
• Molecular Weight: 154.125
• Hs Code.: 2922199090
• Mol file: 33543-55-4.mol

Synonyms:Hydroxylamine,O-(p-nitrophenyl)- (8CI);O-(4-Nitrophenyl)hydroxylamine;O-(p-Nitrophenyl)hydroxylamine;p-Nitrophenoxyamine;

Chemical Property of p-Nitrophenoxyamine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 126-127℃
• Refractive Index: 1.598
• Boiling Point: 313.246 °C at 760 mmHg
• PKA: 1.32±0.70(Predicted)
• Flash Point: 143.246 °C
• PSA: 81.07000
• Density: 1.371 g/cm³
• LogP: 2.07080
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.9% ^*data from raw suppliers

O-(4-Nitrophenyl)hydroxylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-Nitrophenoxyamine

There total 20 articles about p-Nitrophenoxyamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

ethyl O-(4-nitrophenyl)acetohydroxamate (83077-00-3) → p-nitrophenoxyamine (33543-55-4)

Guidance literature:

ethyl O-(4-nitrophenyl)acetohydroxamate; With hydrogenchloride; water; at 25 - 32 ℃; for 1h;

With sodium hydroxide; In water; at 33 ℃; Product distribution / selectivity;

Reference yield: 73.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + O-(p-nitrophenyl)benzohydroximoyl chloride (344266-15-5) → p-nitrophenoxyamine (33543-55-4) + p-nitrophenylbenzoate (959-22-8)

Guidance literature:

With antimonypentachloride; In benzene; at 180 ℃; for 5h;

DOI:10.1021/ja00405a043

Reference yield: 72.0%

N-(4'-nitrophenyloxy)-5-norborene-2,3-dicarboximide → p-nitrophenoxyamine (33543-55-4)

Guidance literature:

With hydrazine hydrate; In dichloromethane; Heating;

DOI:10.1002/(SICI)1099-1395(199905)12:5<357::AID-POC129>3.0.CO;2-Y

upstream raw materials:

N-Boc-O-(4-nitrophenyl)hydroxylamine

4-nitro-phenol

O-(p-nitrophenyl)benzohydroximoyl chloride

ethyl O-(4-nitrophenyl)acetohydroxamate

Downstream raw materials:

O-(4-Nitrophenyl)-4-chlorbenzaldoxim

E-O-p-nitrophenyl-p-nitrobenzaldoxime

(E)-benzaldehyde O-(4-nitrophenyl)oxime

4-nitro-phenol

Refernces

• 1、 Hu, Zhiyong,Liu, Guixia. "Rhodium(III)-Catalyzed Cascade Redox-Neutral C–H Functionalization and Aromatization: Synthesis of Unsymmetrical ortho-Biphenols". supporting information. p. 1643 - 1648. Retrieved 2017/05/22.
• 2、 -. "PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5". . . Retrieved 2013/07/05.