Toluene-4-sulfonic acid (4aR,6R,7R,7aR)-6-(6-dibutylamino-purin-9-yl)-2-hydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid (4aR,6R,7R,7aR)-6-(6-dibutylamino-purin-9-yl)-2-hydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl ester
• CAS No.: 744182-67-0
• Molecular Formula: C₂₅H₃₄N₅O₈PS
• Molecular Weight: 595.613

Synonyms:

Chemical Property of Toluene-4-sulfonic acid (4aR,6R,7R,7aR)-6-(6-dibutylamino-purin-9-yl)-2-hydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl ester

Chemical Property:

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Technology Process of Toluene-4-sulfonic acid (4aR,6R,7R,7aR)-6-(6-dibutylamino-purin-9-yl)-2-hydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl ester

There total 3 articles about Toluene-4-sulfonic acid (4aR,6R,7R,7aR)-6-(6-dibutylamino-purin-9-yl)-2-hydroxy-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cAMP (60-92-4) → Toluene-4-sulfonic acid (4aR,6R,7R,7aR)-6-(6-dibutylamino-purin-9-yl)-2-hydroxy-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl ester (744182-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / aq. NaOH / dioxane / Ambient temperature

2: NaH / 1) DMSO, room temp.

With sodium hydroxide; sodium hydride; In 1,4-dioxane;

DOI:10.1248/cpb.38.3147

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → Toluene-4-sulfonic acid (4aR,6R,7R,7aR)-6-(6-dibutylamino-purin-9-yl)-2-hydroxy-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl ester (744182-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / aq. NaOH / dioxane / Ambient temperature

2: NaH / 1) DMSO, room temp.

With sodium hydroxide; sodium hydride; In 1,4-dioxane;

DOI:10.1248/cpb.38.3147

Reference yield:

1-bromo-butane (109-65-9) + 2'-O-Tosyl cAMP (77056-11-2) → Toluene-4-sulfonic acid (4aR,6R,7R,7aR)-6-(6-dibutylamino-purin-9-yl)-2-hydroxy-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl ester (744182-67-0)

Guidance literature:

With sodium hydride; Multistep reaction; 1) DMSO, room temp.;

DOI:10.1248/cpb.38.3147

upstream raw materials:

1-bromo-butane

2'-O-Tosyl cAMP

cAMP

p-toluenesulfonyl chloride

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