C₁₃H₁₈N₂O

Base Information

• Chemical Name: C₁₃H₁₈N₂O
• CAS No.: 1217460-60-0
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.299
• Mol file: 1217460-60-0.mol

Synonyms:

Chemical Property of C₁₃H₁₈N₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₈N₂O

There total 5 articles about C₁₃H₁₈N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H16N4O → C13H18N2O (1217460-60-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; for 4h; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/ja4043406

Reference yield:

4-methyl-benzoyl chloride (874-60-2) → C13H18N2O (1217460-60-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 4 h / -10 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 22 h / 45 °C / Inert atmosphere

4: palladium on activated charcoal; hydrogen / tetrahydrofuran / 4 h / 760.05 Torr / Inert atmosphere

With sodium azide; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja4043406

Reference yield:

(S)-1-(4-methylbenzoyl)-2-(hydroxymethyl)pyrrolidine (1177999-93-7) → C13H18N2O (1217460-60-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 12 h / 0 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 22 h / 45 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / tetrahydrofuran / 4 h / 760.05 Torr / Inert atmosphere

With sodium azide; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja4043406

upstream raw materials:

(S)-1-Pyrrolidin-2-yl-methanol

4-methyl-benzoyl chloride

(S)-1-(4-methylbenzoyl)-2-(hydroxymethyl)pyrrolidine

Downstream raw materials:

(S)-N-((1-(4-methylbenzoyl)pyrrolidin-2-yl)methyl)benzenesulfonamide