1-(5-CHLOROPYRIDIN-2-YL)METHANAMINE

Base Information

• Chemical Name: 1-(5-CHLOROPYRIDIN-2-YL)METHANAMINE
• CAS No.: 67938-76-5
• Molecular Formula: C6H7 Cl N2
• Molecular Weight: 142.588
• Hs Code.: 2933399090
• Mol file: 67938-76-5.mol

Synonyms:(5-Chloropyridin-2-yl)methanamine

Chemical Property of 1-(5-CHLOROPYRIDIN-2-YL)METHANAMINE

Chemical Property:

• Boiling Point: 216.2±25.0 °C(Predicted)
• PKA: 8.31±0.39(Predicted)
• PSA: 38.91000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 1.89400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(5-Chloropyridin-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-CHLOROPYRIDIN-2-YL)METHANAMINE

There total 5 articles about 1-(5-CHLOROPYRIDIN-2-YL)METHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-cyano-5-chloropyridine (89809-64-3) → (5-chloropyridin-2-yl)methanamine (67938-76-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; for 2h; under 2068.65 Torr;

Reference yield:

diethyl (5-chloro-2-pyridyl)-2-acetamidomalonate (67938-69-6) → (5-chloropyridin-2-yl)methanamine (67938-76-5)

Guidance literature:

diethyl (5-chloro-2-pyridyl)-2-acetamidomalonate; With sodium hydroxide; In ethanol; at 2 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In water; at 18 - 80 ℃;

With sodium hydroxide; In water; pH=10;

Reference yield:

(5-chloro-2-pyridinyl)methanol (209526-98-7) → (5-chloropyridin-2-yl)methanamine (67938-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 2 h / Reflux

With di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; ethanol;

DOI:10.1021/jacs.8b09739

upstream raw materials:

2-cyano-5-chloropyridine

diethyl (5-chloro-2-pyridyl)-2-acetamidomalonate

(5-chloro-2-pyridinyl)methanol

Downstream raw materials:

6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-carbonitrile

1-bromo-6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)imidazo[1,5-a]pyridine

6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)imidazo[1,5-a]pyridine

4-{[(5-chloro-2-pyridinyl)methyl]amino}-3-nitro-N-[(1R)-1-phenylpropyl]benzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 67938-76-5 1-(5-CHLOROPYRIDIN-2-YL)METHANAMINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send