1H-Imidazole,1-(2-methoxyphenyl)-

Base Information

• Chemical Name: 1H-Imidazole,1-(2-methoxyphenyl)-
• CAS No.: 10040-93-4
• Molecular Formula: C10H10 N2 O
• Molecular Weight: 174.202
• Mol file: 10040-93-4.mol

Synonyms:Imidazole,1-(o-methoxyphenyl)- (7CI,8CI); 1-(2-Methoxyphenyl)-1H-imidazole;1-(2-Methoxyphenyl)imidazole; 1-(o-Methoxyphenyl)imidazole

Chemical Property of 1H-Imidazole,1-(2-methoxyphenyl)-

Chemical Property:

• PSA: 27.05000
• LogP: 1.88090

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Methoxyphenyl)-1H-imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole,1-(2-methoxyphenyl)-

There total 13 articles about 1H-Imidazole,1-(2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1H-imidazole (288-32-4) + 4-iodoanisol (529-28-2) → 1-(2-methoxyphenyl)-imidazole (10040-93-4)

Guidance literature:

With copper(l) iodide; N,N′-di-β-D-glucopyranosylethylenediamine; caesium carbonate; In water; at 100 ℃; for 24h;

DOI:10.1055/s-0037-1611695

Reference yield: 95.0%

1H-imidazole (288-32-4) + 2-bromoanisole (578-57-4) → 1-(2-methoxyphenyl)-imidazole (10040-93-4)

Guidance literature:

With potassium phosphate; copper(l) iodide; L-lysine; at 130 ℃; for 6.5h; Microwave irradiation;

DOI:10.1016/j.tetlet.2008.12.119

Reference yield: 93.0%

1H-imidazole (288-32-4) + 2-Methoxyphenylboronic acid (5720-06-9) → 1-(2-methoxyphenyl)-imidazole (10040-93-4)

Guidance literature:

With air; copper(l) chloride; In methanol; for 6h; Heating;

DOI:10.1039/b307734a

upstream raw materials:

1H-imidazole

2-Methoxyphenylboronic acid

4-iodoanisol

imidazolyl sodium

Downstream raw materials:

bis(N-allyl-N-methyl-5'-aminomethyl-1'-methyl-1'H-2'-imidazolyl)[1''-(2''-methoxyphenyl)-1'H-2'-imidazolyl]methyl alcohol

C₁₄H₁₉N₂O₂P

2-(di-1-adamantylphosphino)-1-(2-methoxyphenyl)-1H-imidazole

2-(1-imidazolyl)-4-nitrophenol

Refernces

• 1、 Cao, Changsheng,Lu, Zhongbo,Cai, Zhengyuan,Pang, Guangsheng,Shi, Yanhui. "Cheap Cu(I)/hexamethylenetetramine (HMTA) catalytic system for C-N coupling reactions". . p. 279 - 284. Retrieved 2012.
• 2、 Yang, Haitao,Miao, Zhiwei,Chen, Ruyu. "A versatile and efficient cu-catalyzed N-Arylation of aromatic cyclic secondary amines with aryl halides". . p. 325 - 331. Retrieved 2011.
• 3、 Wang, Xiaochuang,Meng, Fei,Zhang, Jie,Xie, Jianwei,Dai, Bin. "2,6-Bis(2-methylhydrazine-1-carbonyl)pyridine 1-oxide as an Efficient Ligand for Copper-Catalyzed C–N Coupling Reaction in Water". . p. 1142 - 1149. Retrieved 2018.
• 4、 Bell, Nicola L.,Xu, Chao,Fyfe, James W. B.,Vantourout, Julien C.,Brals, Jeremy,Chabbra, Sonia,Bode, Bela E.,Cordes, David B.,Slawin, Alexandra M. Z.,McGuire, Thomas M.,Watson, Allan J. B.. "Cu(OTf)2-Mediated Cross-Coupling of Nitriles and N-Heterocycles with Arylboronic Acids to Generate Nitrilium and Pyridinium Products**". . p. 7935 - 7940. Retrieved 2021.
• 5、 Ghorbani-Vaghei, Ramin,Hemmati, Saba,Veisi, Hojat. "An in situ generated CuI/metformin complex as a novel and efficient catalyst for C-N and C-O cross-coupling reactions". . p. 7095 - 7099. Retrieved 2013.
• 6、 Wu, Feng-Tian,Liu, Ping,Ma, Xiao-Wei,Xie, Jian-Wei,Dai, Bin. "Tetrazole-1-acetic acid as a ligand for copper-catalyzed N-arylation of imidazoles with aryl iodides under mild conditions". . p. 893 - 896. Retrieved 2013.
• 7、 Zhang, Chenlu,Zhu, Hai,Gang, Kaiyue,Tao, Minli,Ma, Ning,Zhang, Wenqin. "Immobilization of copper(II) into polyacrylonitrile fiber toward efficient and recyclable catalyst in Chan-Lam coupling reactions". . . Retrieved 2021.
• 8、 Pai, Gita,Chattopadhyay, Asoke P.. "N-Arylation of nitrogen containing heterocycles with aryl halides using copper nanoparticle catalytic system". . p. 3140 - 3145. Retrieved 2016.
• 9、 Farahat, Abdelbasset A.,Boykin, David W.. "Copper(I) 3-methylsalicylate, an efficient catalyst for N-arylation of heterocycles under moderate reaction conditions". . p. 3049 - 3051. Retrieved 2014.
• 10、 Wu, Feng-Tian,Yan, Nan-Nan,Liu, Ping,Xie, Jian-Wei,Liu, Yan,Dai, Bin. "Copper powder-catalyzed N-arylation of imidazoles in water using 2-(hydrazinecarbonyl)pyridine N-oxides as the new ligands". . p. 3249 - 3251. Retrieved 2014.