Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate

Base Information

• Chemical Name: Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate
• CAS No.: 426829-52-9
• Molecular Formula: C13H19 Cl N4 O2
• Molecular Weight: 298.772
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30592685
• Wikidata: Q82486923
• Mol file: 426829-52-9.mol

Synonyms:426829-52-9;1-N-Boc-4-(6-Chloropyrazin-2-yl)piperazine;TERT-BUTYL 4-(6-CHLOROPYRAZIN-2-YL)PIPERAZINE-1-CARBOXYLATE;6'-Chloro-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester;MFCD07368260;SCHEMBL1432444;DTXSID30592685;XTDKNKUNEVLULA-UHFFFAOYSA-N;AKOS025311097;AB32009;GS-3436;6'-chloro-2,3,5,6-tetrahydro-1,2'-bipyrazinyl-4-carboxylic acid tert-butyl ester;SY122197;1-Boc-4-(6-chloropyrazin-2-yl)piperazine;2-(4-Boc-1-piperazinyl)-6-chloropyrazine;DB-070329;CS-0136779;EN300-1264640;2-chloro-6-(4-t-butoxycarbonylpiperazin-1-yl)pyrazine;Tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate;tert-Butyl 4-(6-chloropyrazin-2-yl)-1-piperazinecarboxylate;tert-butyl-4-(6-chloro-pyrazin-2-yl)-piperazine-1-carboxylate;tert-BUTYL-4-(6-CHLORO-PYRAZIN-2-YL)-PIPERAZINE-1-CARBOXYATE;6'-chloro-2,3,5,6-tetrahydro-[1,2']-bipyrazinyl-4-carboxylic acid tert-butyl ester;6'-chloro-2,3,5,6-tetrahydro-[1,2]bipyrazinyl-4-carboxylic acid tert-butyl ester;6'-chloro-2,3,5,6-tetrahydro-[1,2]bipyrazinyl4-carboxylic acid tert-butyl ester;6-CHLORO-2,3,5,6-TETRAHYDRO-[1,2]BIPYRAZINYL-4-CARBOXYLICACIDTERT-BUTYLESTER

Chemical Property of Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate

Chemical Property:

• PSA: 58.56000
• LogP: 2.19000
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 298.1196536
• Heavy Atom Count: 20
• Complexity: 340

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCN(CC1)C2=CN=CC(=N2)Cl
• Uses: 6''-Chloro-2,3,5,6-tetrahydro-[1,2'']bipyrazinyl-4-carboxylic Acid tert-Butyl Ester

Technology Process of Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate

There total 4 articles about Tert-butyl 4-(6-chloropyrazin-2-YL)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-dichloropyrazine (4774-14-5) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate (426829-52-9)

Guidance literature:

With triethylamine; In acetonitrile; at 120 ℃; for 2h; Microwave irradiation;

Reference yield:

2,6-dichloropyridine (2402-78-0) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate (426829-52-9)

Guidance literature:

With potassium carbonate; In N,N-dimethylimidazolidin-2-one; Heating / reflux;

Reference yield:

2,5-dichloropyrazine (19745-07-4) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate (426829-52-9)

Guidance literature:

2,5-dichloropyrazine; 1-t-Butoxycarbonylpiperazine; With macroporous polymer-supported carbonate; In dimethyl sulfoxide; at 100 ℃;

With macroporous polymer-supported isocyanate; In dichloromethane; at 60 ℃;

DOI:10.1016/j.tetlet.2006.02.047

upstream raw materials:

2,5-dichloropyrazine

1-t-Butoxycarbonylpiperazine

2,6-dichloropyridine

2,6-dichloropyrazine

Downstream raw materials:

2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride

tert-butyl 4-{6-[5-(1-methyl-1H-pyrazol-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}piperazine-1-carboxylate

tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate

tert-butyl 4-(6-phenylpyrazin-2-yl)piperazine-1-carboxylate