tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate
• CAS No.: 1143577-29-0
• Molecular Formula: C₁₉H₂₂F₂N₄O₂
• Molecular Weight: 376.406
• Mol file: 1143577-29-0.mol

Synonyms:tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate

Chemical Property of tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate (426829-52-9) + 2,4-difluorophenylboronic acid (144025-03-6) → tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate (1143577-29-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 20 - 100 ℃;

Reference yield: 75.0%

tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate (1143577-29-0) → 2-(2,4-difluorophenyl)-6-piperazin-1-ylpyrazine (1143577-30-3)

Guidance literature:

tert-butyl 4-[6-(2,4-difluorophenyl)pyrazin-2-yl]piperazine-1-carboxylate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 5h;

With sodium hydroxide; water; pH=11;

upstream raw materials:

tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate

2,4-difluorophenylboronic acid

Downstream raw materials:

2-(2,4-difluorophenyl)-6-piperazin-1-ylpyrazine