N-[(2,3-dimethoxyphenyl)methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride

Base Information

• Chemical Name: N-[(2,3-dimethoxyphenyl)methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
• CAS No.: 102321-59-5
• Molecular Formula: C19H25 N O4 . Cl H
• Molecular Weight: 367.873
• Mol file: 102321-59-5.mol

Synonyms:Benzeneethanamine,N-[(2,3-dimethoxyphenyl)methyl]-3,4-dimethoxy-, hydrochloride (9CI); Phenethylamine, N-2,3-dimethoxybenzyl-3,4-dimethoxy-,hydrochloride (6CI)

Chemical Property of N-[(2,3-dimethoxyphenyl)methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride

Chemical Property:

• Melting Point: 128℃
• PSA: 48.95000
• LogP: 4.24620

Purity/Quality:

99% ^*data from raw suppliers

N-(2,3-Dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanaminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(2,3-dimethoxyphenyl)methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride

There total 5 articles about N-[(2,3-dimethoxyphenyl)methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(2,3-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethan-1-amine (47355-66-8) → N-(2,3-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethan-1-aminium chloride (102321-59-5)

Guidance literature:

With hydrogenchloride; In methanol; water; at 25 ℃; for 0.0833333h;

DOI:10.1021/acs.joc.1c00602

Reference yield:

2,3-dimethyoxybenzaldehyde (86-51-1) → N-(2,3-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethan-1-aminium chloride (102321-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 0.08 h / 25 °C / 5250.53 Torr

2: 10 wt% Pd(OH)2 on carbon; silica gel; hydrogen / methanol / 0.08 h / 60 °C / 15001.5 Torr

3: hydrogenchloride / methanol; water / 0.08 h / 25 °C

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; silica gel; In methanol; water;

DOI:10.1021/acs.joc.1c00602

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-(2,3-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethan-1-aminium chloride (102321-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 0.08 h / 25 °C / 5250.53 Torr

2: 10 wt% Pd(OH)2 on carbon; silica gel; hydrogen / methanol / 0.08 h / 60 °C / 15001.5 Torr

3: hydrogenchloride / methanol; water / 0.08 h / 25 °C

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; silica gel; In methanol; water;

DOI:10.1021/acs.joc.1c00602

upstream raw materials:

2,3-dimethyoxybenzaldehyde

2-(3,4-dimethoxyphenyl)-ethylamine

N-(2,3-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)ethan-1-amine

Downstream raw materials:

2,3,9,10-tetramethoxy-5,8-dihydro-6H-isoquinolino[3,2-α]isoquinoline

tetrahydropalmatine