Technology Process of 10bα-(3-Indolyl)-5-(p-toluenesulfonyl)-7,7,9-trimethyl-5,6aα,7,8,10aβ,10bα-hexahydroindeno-<2,1-b>indole
There total 10 articles about 10bα-(3-Indolyl)-5-(p-toluenesulfonyl)-7,7,9-trimethyl-5,6aα,7,8,10aβ,10bα-hexahydroindeno-<2,1-b>indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 46 percent
2: Dimethylaminopyridine / CH2Cl2 / 4.5 h / 0 - 5 °C
3: 40 percent / 1) MeMgI / 1) ether, 1 h, RT, 2) CH2Cl2, ether, 2 h, 5 deg C
4: oxalyl chloride / benzene / 24 h / Ambient temperature
5: 1) lithiumdiisopropylamide / 1) THF, -15 deg C, 7 h, 2) -15 deg C, 2 h
6: NaH
7: 86 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / 0 °C
8: 75 percent / N,N-dimethylaminopyridine / CH2Cl2 / 72 h / Ambient temperature
9: 1) MeMgI / 1) Et2O, CH2Cl2, 0-5 deg C, 2) 5 deg C, 17 h
With
dmap; lithium aluminium tetrahydride; methyl magnesium iodide; oxalyl dichloride; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; benzene;
DOI:10.1139/v91-141
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 40 percent / 1) MeMgI / 1) ether, 1 h, RT, 2) CH2Cl2, ether, 2 h, 5 deg C
2: oxalyl chloride / benzene / 24 h / Ambient temperature
3: 1) lithiumdiisopropylamide / 1) THF, -15 deg C, 7 h, 2) -15 deg C, 2 h
4: NaH
5: 86 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / 0 °C
6: 75 percent / N,N-dimethylaminopyridine / CH2Cl2 / 72 h / Ambient temperature
7: 1) MeMgI / 1) Et2O, CH2Cl2, 0-5 deg C, 2) 5 deg C, 17 h
With
dmap; lithium aluminium tetrahydride; methyl magnesium iodide; oxalyl dichloride; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; benzene;
DOI:10.1139/v91-141
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl chloride / benzene / 24 h / Ambient temperature
2: 1) lithiumdiisopropylamide / 1) THF, -15 deg C, 7 h, 2) -15 deg C, 2 h
3: NaH
4: 86 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / 0 °C
5: 75 percent / N,N-dimethylaminopyridine / CH2Cl2 / 72 h / Ambient temperature
6: 1) MeMgI / 1) Et2O, CH2Cl2, 0-5 deg C, 2) 5 deg C, 17 h
With
dmap; lithium aluminium tetrahydride; methyl magnesium iodide; oxalyl dichloride; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; benzene;
DOI:10.1139/v91-141
