[3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: [3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 522602-16-0
• Molecular Formula: C13H20 N2 O2
• Molecular Weight: 236.31000
• Hs Code.: 2924299090
• Mol file: 522602-16-0.mol

Synonyms:tert-Butyl (3-(2-aminoethyl)phenyl)carbamate;3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER;[3-(2-AMINO-ETHYL)]-PHENYL-CARBAMIC ACID TERT-BUTYL ESTER;

Chemical Property of [3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 315.3±25.0 °C(Predicted)
• PKA: 13.81±0.70(Predicted)
• PSA: 64.35000
• Density: 1.099±0.06 g/cm3(Predicted)
• LogP: 3.30810

Purity/Quality:

97% ^*data from raw suppliers

[3-(2-Amino-ethyl)-phenyl]-carbamicacidtert-butylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

There total 6 articles about [3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-(3-aminophenyl)ethylamine (76935-75-6) → 3-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine (522602-16-0)

Guidance literature:

With acetic acid; In 1,4-dioxane; water; at 20 ℃; pH=4.5; regioselective reaction;

DOI:10.1055/s-0028-1083290

Reference yield:

[3-(2-Azido-ethyl)-phenyl]-carbamic acid tert-butyl ester (180002-11-3) → 3-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine (522602-16-0)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jm980072p

Reference yield:

2-(3-nitrophenyl)ethanol (52022-77-2) → 3-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine (522602-16-0)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / 10percent Pd/C

3: CBr₄, PPh₃

4: NaN₃

5: H₂ / Pd/C

With sodium azide; carbon tetrabromide; hydrogen; triphenylphosphine; palladium on activated charcoal;

DOI:10.1021/jm980072p

upstream raw materials:

[3-(2-Azido-ethyl)-phenyl]-carbamic acid tert-butyl ester

2-(3-nitrophenyl)ethanol

2-(3-aminophenyl)ethan-1-ol

tert-butyl N-[3-(2-hydroxyethyl)phenyl]carbamate

Downstream raw materials:

[3-(2-Benzyloxycarbonylamino-ethyl)-phenyl]-carbamic acid tert-butyl ester

[2-(3-Amino-phenyl)-ethyl]-carbamic acid benzyl ester