Carbamic acid, [3-(2-hydroxyethyl)phenyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [3-(2-hydroxyethyl)phenyl]-, 1,1-dimethylethyl ester
• CAS No.: 180002-10-2
• Molecular Formula: C13H19NO3
• Molecular Weight: 237.299
• Mol file: 180002-10-2.mol

Synonyms:[3-(2-Hydroxy-ethyl)-phenyl]-carbamic acid tert-butyl ester;tert-butyl 3-(2-hydroxyethyl)phenylcarbamate;tert-butyl [3-(2-hydroxyethyl)phenyl]carbamate;

Chemical Property of Carbamic acid, [3-(2-hydroxyethyl)phenyl]-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 58.56000
• LogP: 2.64140

Purity/Quality:

95%-98% ^*data from raw suppliers

3-N-Boc-aminophenethylalcohol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [3-(2-hydroxyethyl)phenyl]-, 1,1-dimethylethyl ester

There total 7 articles about Carbamic acid, [3-(2-hydroxyethyl)phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-(3-aminophenyl)ethan-1-ol (52273-77-5) → tert-butyl N-[3-(2-hydroxyethyl)phenyl]carbamate (180002-10-2)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;

Reference yield: 61.0%

2-(3-((tert-butoxycarbonyl)amino)phenyl)ethanoic acid methyl ester → tert-butyl N-[3-(2-hydroxyethyl)phenyl]carbamate (180002-10-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/acs.jmedchem.1c00313

Reference yield:

2-(3-nitrophenyl)ethanol (52022-77-2) → tert-butyl N-[3-(2-hydroxyethyl)phenyl]carbamate (180002-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jm980072p

upstream raw materials:

di-tert-butyl dicarbonate

2-(3-aminophenyl)ethan-1-ol

2-(3-nitrophenyl)ethanol

(3-nitrophenyl)acetonitrile

Downstream raw materials:

[3-(2-Benzyloxycarbonylamino-ethyl)-phenyl]-carbamic acid tert-butyl ester

[2-(3-Amino-phenyl)-ethyl]-carbamic acid benzyl ester

[3-(2-Azido-ethyl)-phenyl]-carbamic acid tert-butyl ester

3-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine