1,1-Difluoro-3-phenylpropan-2-ol

Base Information

Chemical Name:1,1-Difluoro-3-phenylpropan-2-ol
CAS No.:145299-86-1
Molecular Formula:C₉H₁₀F₂O
Molecular Weight:172.175
Hs Code.:
European Community (EC) Number:856-129-5

Synonyms:1,1-difluoro-3-phenylpropan-2-ol;145299-86-1;1,1-difluoro-3-phenyl-2-propanol;BGEYWCYUHPALBR-UHFFFAOYSA-N;AKOS017516490;G39771;EN300-1230920

Suppliers and Price of 1,1-Difluoro-3-phenylpropan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
1,1-Difluoro-3-phenylpropan-2-ol
10g
$ 2002.00

AK Scientific
1,1-Difluoro-3-phenylpropan-2-ol
1g
$ 542.00

Total 2 raw suppliers

Chemical Property of 1,1-Difluoro-3-phenylpropan-2-ol

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:172.06997126
Heavy Atom Count:12
Complexity:122

Purity/Quality:

97% ^*data from raw suppliers

1,1-Difluoro-3-phenylpropan-2-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(C(F)F)O

Technology Process of 1,1-Difluoro-3-phenylpropan-2-ol

There total 11 articles about 1,1-Difluoro-3-phenylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 61153-49-9
1,1-difluoro-3-phenylpropan-2-one

: 123986-76-5,123986-83-4,145299-86-1
1,1-Difluoro-3-phenyl-propan-2-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 5h; Ambient temperature;
DOI:10.1016/S0022-1139(00)81174-4

Reference yield:

: 122-78-1
phenylacetaldehyde

: 86847-53-2
bis(trimethylsilyl)difluoromethane

: 123986-76-5,123986-83-4,145299-86-1
1,1-Difluoro-3-phenyl-propan-2-ol

Guidance literature:: With hydrogenchloride; tetrabutyl ammonium fluoride; Yield given. Multistep reaction; 1.) DME, THF, room temperature, 24 h, 2.) water;
DOI:10.1021/ja962990n

Reference yield:

: 61153-49-9
1,1-difluoro-3-phenylpropan-2-one

: 123986-76-5,123986-83-4,145299-86-1
(S)-1,1-Difluoro-3-phenyl-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / sodium borohydride / ethanol / 5 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 6 h / Ambient temperature

3: 1.5 h / 40 - 41 °C / lipase P, pH 7.3

With pyridine; sodium tetrahydroborate; In ethanol; dichloromethane;
DOI:10.1016/S0022-1139(00)81174-4