Brivanib

Base Information

Chemical Name:Brivanib
CAS No.:649735-46-6
Molecular Formula:C19H19FN4O3
Molecular Weight:370.383
Hs Code.:2933990090
European Community (EC) Number:639-685-1
UNII:DDU33B674I
DSSTox Substance ID:DTXSID60215294
Nikkaji Number:J2.765.119D
Wikidata:Q27075503
NCI Thesaurus Code:C67040
Pharos Ligand ID:DU79TW278D4T
Metabolomics Workbench ID:153031
ChEMBL ID:CHEMBL377300
Mol file:649735-46-6.mol

Synonyms:BMS 540215;BMS 582664;BMS-540215;BMS-582664;BMS540215;BMS582664;brivanib;brivanib alaninate

Suppliers and Price of Brivanib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Brivanib
50mg
$ 655.00

Matrix Scientific
1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol 95%
1g
$ 6660.00

Matrix Scientific
1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol 95%
100mg
$ 3330.00

DC Chemicals
Brivanib(bms-540215) >98%
250 mg
$ 1000.00

DC Chemicals
Brivanib(bms-540215) >98%
100 mg
$ 500.00

Crysdot
Brivanib 98+%
50mg
$ 540.00

Crysdot
Brivanib 98+%
10mg
$ 210.00

ChemScene
Brivanib 99.37%
100mg
$ 1188.00

ChemScene
Brivanib 99.37%
50mg
$ 708.00

ChemScene
Brivanib 99.37%
10mg
$ 216.00

Total 57 raw suppliers

Chemical Property of Brivanib

Chemical Property:

Refractive Index:1.66
PKA:14.18±0.20(Predicted)
PSA：84.67000
Density:1.42 g/cm³
LogP:3.51840
Solubility.:insoluble in H2O; ≥18.5 mg/mL in DMSO; ≥3.39 mg/mL in EtOH with ultrasonic
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:370.14411864
Heavy Atom Count:27
Complexity:515

Purity/Quality:

99%, ^*data from raw suppliers

Brivanib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OCC(C)O)C
Isomeric SMILES:CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)O)C
Recent ClinicalTrials:Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated Levels of Plasma FGF
Recent EU Clinical Trials:A Blinded, Randomized, Phase 1/2 Study of Brivanib Alaninate vs. Placebo in Combination with Erbitux and Irinotecan in K-Ras wild type Subjects with Metastatic Colorectal Cancer.
Uses Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively.

Technology Process of Brivanib

There total 10 articles about Brivanib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 649735-41-1
4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol

: 15448-47-2
(R)-propylene oxide

: 649735-46-6
Brivanib

Guidance literature:: With triethylamine; lithium chloride; In ethanol; at 70 ℃; for 3h;
DOI:10.1021/jm7013309

Reference yield:

: C₁₆H₁₂FN₄O₂^(1-)*Na⁽¹⁺⁾

: 15448-47-2
(R)-propylene oxide

: 649735-46-6
Brivanib

Guidance literature:: In water; acetonitrile; at 28 ℃; for 20 - 24h;

Reference yield:

: 288385-88-6
4-fluoro-2-methyl-1H-indol-5-ol

: 649735-46-6
Brivanib

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / -78 - 20 °C

1.2: dimethylformamide / 1 h / 20 °C

2.1: 86 percent / HCOONH₄ / Pd/C / dimethylformamide / 1.5 h / 20 °C

3.1: 53 percent / Et₃N / ethanol / 2 h / 70 °C

With ammonium formate; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm051106d