Technology Process of 3-(2,2'-bipyridin-4-yl)prop-2-yn-1-ol
There total 4 articles about 3-(2,2'-bipyridin-4-yl)prop-2-yn-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); triethylamine;
In
1,2-dimethoxyethane;
at 120 ℃;
for 3h;
Microwave irradiation;
DOI:10.1016/j.jinorgbio.2014.02.001
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3-chloro-benzenecarboperoxoic acid / 24 h / 40 °C
2: sulfuric acid; nitric acid / 9 h / Reflux
3: Acetyl bromide; phosphorus tribromide / 1.25 h / 40 °C / Reflux
4: tetrakis(triphenylphosphine) palladium(0); triethylamine / 1,2-dimethoxyethane / 3 h / 120 °C / Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); Acetyl bromide; sulfuric acid; nitric acid; phosphorus tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
1,2-dimethoxyethane;
4: |Sonogashira Cross-Coupling;
DOI:10.1016/j.jinorgbio.2014.02.001
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid / 9 h / Reflux
2: Acetyl bromide; phosphorus tribromide / 1.25 h / 40 °C / Reflux
3: tetrakis(triphenylphosphine) palladium(0); triethylamine / 1,2-dimethoxyethane / 3 h / 120 °C / Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); Acetyl bromide; sulfuric acid; nitric acid; phosphorus tribromide; triethylamine;
In
1,2-dimethoxyethane;
3: |Sonogashira Cross-Coupling;
DOI:10.1016/j.jinorgbio.2014.02.001
