6-(4-fluorophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile

Base Information

Chemical Name:6-(4-fluorophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile
CAS No.:366022-33-5
Molecular Formula:C₁₃H₆F₄N₂O
Molecular Weight:282.197
Hs Code.:
European Community (EC) Number:646-577-8
Wikidata:Q27207849
ChEMBL ID:CHEMBL1413543
Mol file:366022-33-5.mol

Synonyms:366022-33-5;6-(4-fluorophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile;6-(4-Fluorophenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile;6-(4-fluorophenyl)-2-hydroxy-4-(trifluoromethyl)nicotinonitrile;4-(TRIFLUOROMETHYL)-6-(4-FLUOROPHENYL)-1,2-DIHYDRO-2-OXOPYRIDINE-3-CARBONITRILE;MLS000736345;CHEMBL1413543;CHEBI:120047;HMS2651K07;MFCD03934050;AKOS005086743;AKOS017344383;SMR000338295;2T-0865;Q27207849;6-(4-fluorophenyl)-2-hydroxy-4-(trifluoromethyl)pyridine-3-carbonitrile;6-(4-Fluorophenyl)-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinecarbonitrile;6-(4-FLUOROPHENYL)-2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

Suppliers and Price of 6-(4-fluorophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-(TRIFLUOROMETHYL)-6-(4-FLUOROPHENYL)-1,2-DIHYDRO-2-OXOPYRIDINE-3-CARBONITRILE 95.00%
10G
$ 7882.88

American Custom Chemicals Corporation
4-(TRIFLUOROMETHYL)-6-(4-FLUOROPHENYL)-1,2-DIHYDRO-2-OXOPYRIDINE-3-CARBONITRILE 95.00%
5G
$ 4244.63

American Custom Chemicals Corporation
4-(TRIFLUOROMETHYL)-6-(4-FLUOROPHENYL)-1,2-DIHYDRO-2-OXOPYRIDINE-3-CARBONITRILE 95.00%
1G
$ 1030.84

Total 3 raw suppliers

Chemical Property of 6-(4-fluorophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:282.04162547
Heavy Atom Count:20
Complexity:530

Purity/Quality:

99% ^*data from raw suppliers

4-(TRIFLUOROMETHYL)-6-(4-FLUOROPHENYL)-1,2-DIHYDRO-2-OXOPYRIDINE-3-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC(=C(C(=O)N2)C#N)C(F)(F)F)F

Technology Process of 6-(4-fluorophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile

There total 2 articles about 6-(4-fluorophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 582-65-0
1-(4-fluorophenyl)-4,4,4-trifluoro-1,3-butanedione

: 107-91-5
cyanoacetic acid amide

: 366022-33-5
6-(4-fluoro-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In ethanol; at 20 ℃; Reflux;
DOI:10.1016/j.bmcl.2014.01.075

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 366022-33-5
6-(4-fluoro-phenyl)-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol; tetrahydrofuran / 0 - 20 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / ethanol / 20 °C / Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; sodium methylate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.bmcl.2014.01.075